Checking titers

[dut]

Hello

 

Apologies if this is a dumb question....

 

If I'm understanding it right the streptozyme test looks for 5 antibodies to strep exoenzymes that includes ASO, antiDNase B, anti-hyaluronidase,(AH), anti-nicotinamide adenine nucleotidase, (ANAD), and anti-streptokinase, (ASK).

 

Why is it when drs are checkign ASO and AntiDNase B they don't run the streptozyme routinely or if they do nut run that amalgamated test, why are they not running all the individual antibody tests for those included in the streptozyme test?

 

It's just that last year our dd came back negative (repeatedly) for ASO and AntiDnaseB but elevated for IgM streptozyme......

 

Thanks for any ideas...

[faith]

dut,

where did you get these kind of tests done? are you indicating that those are included in the ASO and Anti Dnase, but they can also be done individually? I've not heard of those before. Is that what its called... "streptozyme" tests? Did the doc who did that testing think it indicated anything interesting?

 

Faith

[Suzan]

http://www.ncbi.nlm.nih.gov/pmc/articles/P...o00112-0093.pdf

 

I found this.... I read the short version and the discussion, now I have to go back and find out what all those acronyms are, this could be helpful in our case since we have low titers. I'll ask our immunologist about it this Friday.

 

Susan

 

Edit, PS... super old paper, maybe more recent info available...

[dut]

Faith.. hello... if I understand it right ASO and antiDNaseB are in the streptozyme test, as well as three others. You don't get individual results for them, the streptozyme test just shows if 1 or more are present but not which ones.

 

I just wondered why that test or all of the others, individually, aren't done 'cos our dd came back as elevated on the streptozyme test but not ASO or antidnaseB which indicated to me that she had antibodies to one of the other three types of exoenzyme.

 

I don't get hung up on titers but thought it may be extra ammunition for parents if more exoenzymes were checked. Perhaps some kids make them to some but not others.. I just wondered why the focus seems to be ASO and antiDNaseB?

[dut]

Suzan.. hello... yeh I read that paper last night but most of it went straight out of that hole in the back of my head where my brain used to be prior to sleep deprivation :-) but certainly got the sense from it that maybe this test is important for those with low titers.....although another thing I read said that if you add in the antiDNaseB test the you increase sensitivity enough to not need streptozyme but that didn't make sense to me in that the streptozyme test looks for 3 totally different exoenzymes.....?

[faith]

thanks, that's food for thought......(.altho I'll have to get back to this later, got people bothering me here, can't concentrate...... )

 

Faith