High dose azith* Can you still get strep?

[nevergiveup]

My pediatrician use to think it was ridiculous to swab my dd when she had a sore throat while she was on preventative penicillin VK. She would say she cannot get strep while on Pen VK. I know some strep is resistent to azith, so my question is has anyone ever had their children test positive or have a raise in strep titers while on high dose azith (250 mg per day or more depending on childs weight)

 

I know azith gets intracellular strep and is immune modulating, but doesn't it also expose our kids to potential full blown pandas again. If I think my child may have been exposed to strep should I switch her abx just to be conservative? (Even if she is not showing any symptoms at this point). And with a long half life of azith how long should one wait to switch?

[peglem]

I'm not following. How does it expose our kids to full blown PANDAS?

[nevergiveup]

Because they are not protected from all strains of strep.

 

I'm not following. How does it expose our kids to full blown PANDAS?

[peglem]

Aaaahhhh, okay. I should probably get some sleep, I completely missed that!

[nojo]

This doesn't quite answer your question, but it hopefully will add to the discussion. We did just test positive on a rapid test while on augmentin (600mg) but the long term culture came back negative. Our pediatrician said this means we were negative, and that we just have dead cells left over in our throat, but I'm not really totally buying it. In the few days waiting for the culture to come back, my daughter broke out into full strep rash. I kind of feel that is an indicator that things aren't really working right.

[Ellen]

Does anyone know if there is any antibiotic that does protect against all strains of strep? My son is on Zithromax and allergic to Amoxicillin/Augmentin. If Zith does not protect against all strains to strep, I want to know what my options are if he comes down with a strep infection while on Zith.

 

Ellen

 

Because they are not protected from all strains of strep.

 

I'm not following. How does it expose our kids to full blown PANDAS?

[momto2pandas]

Have you had your dd's immunoglobulin's checked yet? My understanding is that if the immune system is deficient, antibiotics won't always work even if that particular strain is antibiotic-susceptible.

 

 

My pediatrician use to think it was ridiculous to swab my dd when she had a sore throat while she was on preventative penicillin VK. She would say she cannot get strep while on Pen VK. I know some strep is resistent to azith, so my question is has anyone ever had their children test positive or have a raise in strep titers while on high dose azith (250 mg per day or more depending on childs weight)

 

I know azith gets intracellular strep and is immune modulating, but doesn't it also expose our kids to potential full blown pandas again. If I think my child may have been exposed to strep should I switch her abx just to be conservative? (Even if she is not showing any symptoms at this point). And with a long half life of azith how long should one wait to switch?

[nevergiveup]

Yeah, she has CVID and gets monthly infusions. I know what your thinking, abx doesn't kill strep just weakens it so the immune system can then attack it easier. I think this is a rather simplified version of the process. So I guess exposure to strep will still cause her to get strep, whether she is on abx or not. Its just whether or not she will start over producing antibodies against it. Maybe thats the reason why these kids still react when family members have strep because they have it too just not anything that the doc can measure in their throat becuz they are on abx. I guess then strep titers is a better measurement of recent exposure?

And when exposed even in small doses creates an immune response. If I can get this why can't the neurologists get this too. And move these kids on the immun docs?

 

Have you had your dd's immunoglobulin's checked yet? My understanding is that if the immune system is deficient, antibiotics won't always work even if that particular strain is antibiotic-susceptible.

 

 

My pediatrician use to think it was ridiculous to swab my dd when she had a sore throat while she was on preventative penicillin VK. She would say she cannot get strep while on Pen VK. I know some strep is resistent to azith, so my question is has anyone ever had their children test positive or have a raise in strep titers while on high dose azith (250 mg per day or more depending on childs weight)

 

I know azith gets intracellular strep and is immune modulating, but doesn't it also expose our kids to potential full blown pandas again. If I think my child may have been exposed to strep should I switch her abx just to be conservative? (Even if she is not showing any symptoms at this point). And with a long half life of azith how long should one wait to switch?

[momto2pandas]

I even wonder if the titers get messed up with immune deficiencies - wouldn't they? Titers are just measures of antibodies, right? I have had some mysterious results where I didn't get the expected titers afterwards event to known infections. I never thought much of it until my immuno started talking immune deficiency.

 

 

 

Yeah, she has CVID and gets monthly infusions. I know what your thinking, abx doesn't kill strep just weakens it so the immune system can then attack it easier. I think this is a rather simplified version of the process. So I guess exposure to strep will still cause her to get strep, whether she is on abx or not. Its just whether or not she will start over producing antibodies against it. Maybe thats the reason why these kids still react when family members have strep because they have it too just not anything that the doc can measure in their throat becuz they are on abx. I guess then strep titers is a better measurement of recent exposure?

And when exposed even in small doses creates an immune response. If I can get this why can't the neurologists get this too. And move these kids on the immun docs?

 

Have you had your dd's immunoglobulin's checked yet? My understanding is that if the immune system is deficient, antibiotics won't always work even if that particular strain is antibiotic-susceptible.

 

 

My pediatrician use to think it was ridiculous to swab my dd when she had a sore throat while she was on preventative penicillin VK. She would say she cannot get strep while on Pen VK. I know some strep is resistent to azith, so my question is has anyone ever had their children test positive or have a raise in strep titers while on high dose azith (250 mg per day or more depending on childs weight)

 

I know azith gets intracellular strep and is immune modulating, but doesn't it also expose our kids to potential full blown pandas again. If I think my child may have been exposed to strep should I switch her abx just to be conservative? (Even if she is not showing any symptoms at this point). And with a long half life of azith how long should one wait to switch?

[EAMom]

This doesn't quite answer your question, but it hopefully will add to the discussion. We did just test positive on a rapid test while on augmentin (600mg) but the long term culture came back negative. Our pediatrician said this means we were negative, and that we just have dead cells left over in our throat, but I'm not really totally buying it. In the few days waiting for the culture to come back, my daughter broke out into full strep rash. I kind of feel that is an indicator that things aren't really working right.

 

How much does your dd weigh? Was she taking the Augmentin as 300 mg 2x daily....or 600mg 1x daily?