I'm scared

[kim]

Susan,

 

Whew! Glad you said "white filling." Personally, I won't even walk in the door of a dentist's office that is using amalgam (mercury) anymore. No, I don't know anything horrible about composite fillings

 

I'm glad that your daughters B12 has been checked. There was another thread about nitrous oxide here, not too long ago. You can look at the site in the first post to see how B12 and folate play into a cycle that can cause some problems if not functioning properly and see how the cysteine/homocysteine/methionine pathways interact. http://www.latitudes.org/forums/index.php?...st=0#entry42531

 

There are quite a few pub med abstracts regarding low B12 and nitrous oxide use. Most talk about problems with longer term use than what your daughter probably would have been exposed to tho. I guess I would just do some reading, let your DAN know if you suspect the nitrous was a problem, and get his/her opinion. When you look at this info. and consider that NAC has been shown to help some people with OCD, it just seems resonable to learn a little about this.

 

A few things from P med

 

http://www.ncbi.nlm.nih.gov/pubmed/8250714...ogdbfrom=pubmed

 

Vitamin B12 (cyanocobalamin) is an integral component of two biochemical reactions in man: the conversion of L-methylmalonyl coenzyme A into succinyl coenzyme A and the formation of methionine by methylation of homocysteine.

 

 

http://www.ncbi.nlm.nih.gov/pubmed/1845855...ogdbfrom=pubmed

 

Nitrous oxide in pediatric anesthesia: friend or foe?

 

 

http://www.ncbi.nlm.nih.gov/pubmed/1768339...ogdbfrom=pubmed

 

When nitrous oxide is no laughing matter: nitrous oxide and pediatric anesthesia.

 

 

Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.

 

Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia. If unrecognized, the neurologic deterioration becomes irreversible and may result in death.

 

 

http://www.ncbi.nlm.nih.gov/pubmed/1762385...ogdbfrom=pubmed

 

Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia: case report and literature review.

 

Muscle Nerve. 2008 Jan;37(1):125-9.

 

Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia: case report and literature review.

Singer MA, Lazaridis C, Nations SP, Wolfe GI.

 

Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8897, USA. mike.singer@utsouthwestern.edu

 

A previously healthy 27-year-old woman developed a subacute myeloneuropathy after receiving nitrous oxide anesthesia for dental procedures. Neurologic evaluation revealed that she was vitamin B(12) deficient due to underlying pernicious anemia. Discontinuation of nitrous oxide and supplementation with vitamin B(12) resulted in dramatic clinical improvement, with near-complete normalization of her neurologic examination. This case and published reports reviewed here emphasize that favorable outcomes are possible following prompt recognition and treatment of vitamin B(12) deficiency.

 

 

http://www.ncbi.nlm.nih.gov/pubmed/1916962...ogdbfrom=pubmed

 

Neurol Sci. 2009 Feb;30(1):75-6. Epub 2009 Jan 24.

 

Subacute combined degeneration of the spinal cord caused by nitrous oxide anaesthesia.

Renard D, Dutray A, Remy A, Castelnovo G, Labauge P.

 

Department of Neurology, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029 Nîmes Cedex 4, France. dimitrirenard@hotmail.com

 

Vitamin B12 deficiency causes haematological, gastrointestinal and neurological diseases. Subacute combined degeneration (SCD) of the spinal cord is characterised by degeneration of the posterior and lateral columns. We report a case of SCD associated with nitrous oxide anaesthesia.

[Suzan]

Thanks Kim! Pretty amazing stuff. Luckily her B12 was normal. I'll bring it up with our Dan! though just in case. Our therapist appt tomorrow has been cancelled due to the therapist has H1N1. So now it's not until the end of the month.

 

Susan

[kim]

saw someone mention dental procedures on another thread and wanted to leave this somewhere. We don't go near amalgam here (silver fillings).

 

http://jdr.sagepub.com/cgi/content/abstract/77/6/1415

 

Activation of the Immune System and Systemic Immune-Complex Deposits in Brown Norway Rats with Dental Amalgam Restorations

[momto2pandas]

I had that experience too. My son needed emergency dental work on Christmas eve, of all times - he was in screaming pain with toothache. We were worried about the PANDAS but had no choice. As soon as he got off of the dentist's chair, my heart sunk. Huge pupils, huge purple circles, throwing fits all the way home. I spent the next several days wondering if he would ever be the same again. He had already been on Zith prior to the work, and the dentist added 10 days of clindamycin to the zith afterwards. He started to get better after about 4 bad days, and was pretty much back to baseline after 7 days, though a little wobblier than usual. So our vacation was kind of lousy, but at least he was well in time to go back to school with no issues.

 

DD8 had a cavity filled yesterday. We used the laughing gas since she was so fearful of the shot. I called our immunologist before to make sure she thought it was OK after all the talk about things happening after dental work. We agreed that she needed the tooth filled otherwise she'd have to have it removed at some point which would be worse.

 

Today she is showing more signs of OCD than I've ever seen before. She pretty out of control. I just gave her a 5-htp and a benadryl to try to calm her down. She wants to play cards with her sister but she won't stop yelling and whining and complaining about all the rules not being followed correctly. Her sister said no way would she play any more (I can't blame her and frankly I'm glad it's over) but now dd8 won't stop saying "I want to play cards" over and over like she's going to die if she can't play cards. DD7's birthday is today. I think it's going to be a horrible bust. No way will dd8 be able to handle it. She's organizing all the party favors and if anyone changes them she's falling out. That's just a small example of what the entire day has been like. I'm a wreck.

 

What if I totally screwed her up by getting that filling yesterday? What if she doesn't come back? I'm really scared. Should I call our immunologist? I don't know what she would do.

 

Susan