The mouse model

[peglem]

I've only seen articles about the mouse model, not the actual article or even the abstract, but I was wondering if there was a particular strain of GABHS that was used to produce the PANDAS reaction in the mice? Seems like it would have to be a strain that presents the particular antigens that Cunningham is finding antibodies to...or is it the child's immune system making renegade antibodies?

 

Oh, wait, I found the abstract:

 

http://www.ncbi.nlm.nih.gov/sites/entrez

 

It says

These antibodies are directed against group A beta-hemolytic streptococcus matrix (M) protein and cross-react with molecular targets complement C4 protein and alpha-2-macroglobulin in brain.

So do all GABHS strains have the M protein?

 

Oh, wait, I see the link doesn't take you to the abstract, so here's the index#

 

PMID: 19668249 [PubMed - as supplied by publisher

[PANDAS_Denmark]

Hi )

 

The entire article is here - in PDFformat : http://www.sarnet.org/doc/PANDAS_Mol_Psychiatry_2009.pdf.

 

Best wishes -

PANDAS_Denmark

[peglem]

Wow, Thanks!