OT; Cipro prescribed

[ilovedogs]

Hello all, this question is for me. I was wondering if anyone had any experience with Cipro? It's in a class of antibiotics that is fluoridated and can have serious side effects. I was put on it here on vacation in FL b/c I got stung by a sting ray. I'm not concerned about the stomach upset, etc. but I am about the potential tendon problems and sun sensitivity. I am already dealing with tendonitis in my elbow so I really don't want to aggravate it. Should I wait until morning and have them put me on a different antibiotic? Or is that futile b/c the bacteria in the Gulf of Mexico only responds to particular antibiotics??? I'm so confused and it doesn't help that I'm in pain either!

 

Bonnie

[ccc]

I have taken it with no problems but when my husband took it it caused him to have numbness in his toes and finger tips. It was not permanent. As soon as he stoped taking it within a few days it was better. I think it depends on each individual. That probably does not help but if you are concerned I would ask the doctor for something else.

[kim]

Bonnie,

 

I just did some reading on these drugs a couple of days ago for someone. I actually thought about posting it here as I thought it would be good info for anyone to have. I get feeling a little like an alarmist at times though. Just going to leave you the info that I have saved and you can draw your own conclusions. This drug was prescribed for my son (13 at the time) for a staph infection. I didn't give it to him and I'm really glad I didn't. The antibiotic that I did give him (Keflex if i remember right) worked just fine. Please let us know what you decide and how you're doing

 

http://www.fluoroquinolones.org/FLOX%20REPORT-REV%2011.pdf

Floxed

 

excerpt from this article, in case you do decide to take it, or find that it might truly be necessary for your situation...but do read the whole thing!!!

 

1. ADJUST THE TREATMENT

According to your weight. For instance, if you weigh some 120 pounds, then take 2x400 mg cipro

instead of 2x500 mg, (assuming that this is the dose that they have prescribed you).

2. TAKE MAGNESIUM

Magnesium interferes with the absortion of quinolones. Therefore, if you take your two-cipro pills

along with your breakfast and dinner, take some magnesium with your lunch, so it does not impair

cipro absorption but keeps your blood magnesium levels high. It has some protective role over

many tissues.

3. DRINK A LOT OF SPRING WATER DURING THE TREATMENT

It helps to maintain an adequate hydration of the tissues and facilitate the elimination of the drug

and the metabolites through the kidneys.

4. AVOID STEROIDS

Do not take any steroids during the treatment with quinolones, unless completely necessary. They

dramatically increase the risk of severe injuries. Take into account that certain treatments do

request the combined therapy, so disregard this advice if you cannot avoid steroids.

5. AVOID NON STEROIDAL ANTIINFLAMMATORIES (NSAIDs)

They amplify the negative effects of fluoroquinolones, specially the risk of central nervous system

occurrences, and neuropathies.

6. BE CAREFUL WITH INTERACTIONS

Some drugs cause dangerous interactions with quinolones. All are included in the package insert,

so read the drug insert because there is quite a great chance that your doctor does not or has not

read it.

 

 

 

 

 

 

 

 

http://www.pubmedcentral.nih.gov/picrender...mp;blobtype=pdf

 

The molecular mechanisms blamed for quinolone chondrotoxicity

include a deficiency of functionally available magnesium

(7, 23, 26), inhibition of mitochondrial dehydrogenase

and proteoglycan synthesis (11, 12), an altered metabolism of

DNA (12, 16, 29) including inhibition of DNA polymerase

(19), tissue accumulation of fluoride (18), and an increase of

the respiratory burst in chondrocytes (10, 30). Nitric oxideinduced

programmed cell death is an important mechanism in

cartilage (2), and ciprofloxacin was reported to enhance production

of the apoptogenic interleukin-1 (1). However, we

could not detect an influence of quinolones on the rate of

chondrocytes undergoing apoptosis.

The chondrotoxic effects of quinolone antimicrobial agents

described here do not necessarily indicate clinically relevant

cartilage damage in human adults.

 

 

 

http://journal.shouxi.net/html/qikan/lcyx/...831_427331.html

 

In summary, the present study provides data indicating that supplementation with magnesium and vitamin E alone or in combination may relevantly diminish joint cartilage lesions induced by quinolones in immature rats. An additive effect of combined supplementation with magnesium and vitamin E was observed. The data further support the proposed pathomechanism of quinolone-induced arthropathy and its sequence with the lack of functionally available magnesium caused by chelation, which leads to increased oxidative stress and the characteristic destruction of cartilage.

 

 

http://www.sciencedirect.com/science?_ob=A...64339708a42bcd0

 

Fluoroquinolones cause changes in extracellular matrix, signalling proteins, metalloproteinases and caspase-3 in cultured human tendon cells

 

 

http://www.springerlink.com/content/p8qb2e3yhpxvhnaw/

 

Recently, we showed that magnesium deficiency induces lesions in knee joint cartilage from 5-week-old rats that are very similar to ofloxacin-induced cartilage defects. We concluded that quinolone-induced arthropathy is probably due to chelation of magnesium and thus a deficit in functionally available magnesium in joint cartilage (Stahlmann et al. 1995). As magnesium deficiency in joint cartilage could impair chondrocyte-matrix interaction which is mediated by cation-dependent integrin receptors of the β1-subfamily, we investigated integrin expression in joint cartilage from untreated, ofloxacin-treated and magnesium-deficient Wistar rats.

[kim]

Bonnie...i forgot to add that the lady who got me looking at this ended up with a torn meniscus (very painful) after taking this drug.

 

http://www.arthroscopy.com/sp05005.htm

[ilovedogs]

Bonnie...i forgot to add that the lady who got me looking at this ended up with a torn meniscus (very painful) after taking this drug.

 

http://www.arthroscopy.com/sp05005.htm

And, this is exactly why I want to avoid it. Quite frankly I'd like to avoid all antibiotics at all costs, but they insist that the reactions from a secondary infection will be far worse. Apparently it's because of the depth of penetration of the barb in the foot. The good news is that there are no signs of a barb in my foot and that it looks clean and very minor right now. I'll be keeping a close eye on it, soaking it when I can, treating with a topical antibiotic, and I will get a new prescription in the AM to better tackle a 'maybe' secondary infection. Guess sometimes it's smart to not take chances, right?

 

Geez, what did people do before antibiotics? You know, I was the 4th person who got stung by 1:30 in the afternoon. Needless to say, we'll be staying away from the Gulf waters for the rest of our trip!

 

B

[ilovedogs]

Bonnie...i forgot to add that the lady who got me looking at this ended up with a torn meniscus (very painful) after taking this drug.

 

http://www.arthroscopy.com/sp05005.htm

Kim, I'm thinking I'll ask for the Keflex or for augmentin. They already gave me a prescription for a yeast infection since I always get those when I take antibiotics! Thanks for the links!

[kim]

Bonnie,

 

It was a sting ray? I was thinking jelly fish when i first read your post.

[guy123]

http://www.latitudes.org/forums/index.php?...ic=4443&hl=

[ilovedogs]

Bonnie,

 

It was a sting ray? I was thinking jelly fish when i first read your post.

Yep, it was a ray! I haven't felt pain like that since I gave birth, it was unbelievable! I'm still sore today but I got the doc to change the prescription to Keflex. I need to call my naturopath today and ask him for advice on how to handle the antibiotic if I get any adverse side effects but I found that Keflex has lesser side effects than Cipro.

[kim]

Bonnie, I think Keflex is one of the older anti biotics with a pretty good safety profile too. Have to ask, did they want you to get a tetanus shot? Anyway, hope you're doing better. Walking around in childbirth pain would not be a good thing while vacationing!

 

Geez, what's up with the sting rays? Guy, I'm not researching it, so you'll have to see if there are any new toxins that could be making the sting rays nervous, K?

 

ccc, if you look at Guys link, you'll see where it talks about cipro being cumulative. If your husband had a mild reaction to it once, I would really think he should avoid it in the future if at all possible. The link for the article "FLOXED" is slow going to get through but it does have a lot of good info.

 

It was so interesting to see all of the info regarding deficient magnesium being a problem with the use of this class of drugs. It says in the floxed article that it doesn't do any good to supplement after tendon injury occurs. Also...that **** flouride. Flouride has been suspected of contributing to osteosarcoma (cancerous tumor at the end of long bones). My son who this was prescribed for, already has an abnormal growth at the end of a long bone. I was going to risk this drug for a tiny spot of staph that you couldn't even see

anymore by the time he got to the Ped? Someone on the PANDAS forum posted about a remark a Dr made about "Mom's practicing playground medicine," wonder who really came off the playground!!!!!

 

Then the questionable prescribing stuff......

 

from wiki

 

http://en.wikipedia.org/wiki/Quinolone

 

"For example the use of the fuoroquinolones had increased three-fold in an emergency room environment in the United States between 1995 and 2002, while the use of safer alternatives such as macrolides declined significantly.[38][39]

 

Fluoroquinolones had become the most commonly prescribed class of antibiotics to adults in 2002. Nearly half (42%) of these prescriptions were for conditions not approved by the FDA, such as acute bronchitis, otitis media, and acute upper respiratory tract infection, according to a study that was supported in part by the Agency for Healthcare Research and Quality.[40][41]. Additionally they are commonly prescribed for medical conditions that are not even bacterial to begin, with such as viral infections, or those to which no proven benefit exist.

 

Within a recent study concerning the proper use of this class in the emergency room it was revealed that 99% of these prescriptions were in error. Out of the one hundred total patients studied, eighty one received a fluoroquinolone for an inappropriate indication. Out of these cases, forty three (53%) were judged to be inappropriate because another agent was considered first line, twenty seven (33%) because there was no evidence of a bacterial infection to begin with (based on the documented evaluation), and eleven (14%) because of the need for such therapy was questionable. Out of the nineteen patients who received a fluoroquinolone for an appropriate indication, only one patient out of one hundred received both the correct dose and duration of therapy

[ilovedogs]

Kim, yes they did want to give a tetanus shot but the doctor admitted that the risk is very minimal anyway so I refused it. I had a friend who had a terrible reaction to a tetanus shot and that was the last thing I wanted to deal with. I figured the antibiotics alone were pushing it with me! Actually, the hotel doctor on call told me the risk of tetanus was minimal as well as the clinic doc, so I gathered it was safe to decline and they didn't push it on me either, which was nice!

 

Now, if this aching and soreness in my foot would go away I'd be able to enjoy our vacation!

 

B

[kim]

when i ended up in ER with the infection induced rash, the male nurse said he felt like a used car salesman, dealing with me, lol. I was wearing a jean shirt, and acted like I was swallowing two pills that gave me (i really made one smooth movement and dropped them in the breast pocket ot the shirt). My sister didn't even see me do it. I had to look up what I was taking first. I also declined the steroid injection (he threw it in the trash). Turns out that was a good move, I was already taking oral steroids from previous trip to a walk in place for the same thing (only it got MUCH worse) and the injection could have made things worse with what was happening with me. You must have been putting out some of the same type of vibes!