Irregular heartbeat/palpatations

[kim]

Wondering if anyone has any comments on this. I have a history of heart palpatations. It started in about 6th grade.

 

The first is from the article that browneyesmom posted recently and something that I was trying to get a handle on a while back (the CaM kinases stuff). I found this article when researching my strep induced psoriasis outbreak. I have a few studies on that, will be posting. I'm having a hard time thinking that this is just a coincidence and remember, I have never considered my boys PANDAS due to the lack of "explosive onset." Anyway.......

 

 

http://www.cpementalhealth.com/content/4/1/13

 

Other putative pathogenetic mechanisms of PANDAS include molecular mimicry and autoimmune-mediated altered neuronal signaling, involving calcium-calmodulin dependent protein (CaM) kinase II activity.

 

 

 

http://www.medicalnewstoday.com/articles/106098.php

 

Study Identifies New Mechanism Linking Activation Of Key Heart Enzyme And Oxidative Stress

 

 

The UI researchers and colleagues from Vanderbilt University in Nashville, Tenn., focused on calmodulin kinase II, or CaM kinase II, a well-studied enzyme critical to many fundamental processes including heartbeat and thought.

 

Scientists know that CaM kinase's activity is sustained by adding a phosphate group -- a process known as phosphorylation. The new study proves that oxidation -- adding oxygen -- also can sustain the enzyme's activity, and like phosphorylation, the mechanism can be reversed to inactivate the kinase.

 

"Our results suggest that oxidation of CaM kinase is a dynamic and reversible process that may direct cell signaling in health and disease," said Mark Anderson, M.D., Ph.D., UI professor of internal medicine and molecular physiology and biophysics and senior study author. "Because CaM kinase activity is involved in arrhythmias, hypertrophy and heart cell death, this work also provides new insights into a disease pathway in heart that may lead to development of new drugs to treat heart disease."