Question

[Darla]

Bit of a technical question, can't seem to find answer for, maybe there isn't one as of yet. My question is in PANDAS the immune system sends off the cross-reactive antibodies and are thought to recognize epitopes on basal ganglia neurons. The resulting inflammation disrupts basal ganglia function that lasts for weeks with all the symptoms following. My question is do we know what specific epitopes are being recognized by these “antineuronal” antibodies? OR If the antibodies are interacting with a specific receptor or a single neuronal cell-type?

 

I know this is heavy stuff, i've been trying to understand it all day today.

 

I came across a drug that reduces inflamation in the hippocampal called minozac, a totally different part of the brain. Is there a drug that can do the same for the basil ganglia? OR suppliments? I read about vitamin D decreasing inflammatory cytokines in the brain, and also how it stimulates the neurotrophin release which induces the survival of the nerve cells.

 

any thoughts????