Flu vaccine

[kim]

This is a 2008 pub med article. They are discussing Guillain-Barré syndrome but the anti GM antibodies statement caught my attention. Does anyone have any thoughts here? bolding mine

 

http://www.ncbi.nlm.nih.gov/pubmed/18522505

 

along with several contemporary vaccines were tested for hemagglutinin (HA) activity, the presence of Campylobacter DNA, and the ability to induce anti-Campylobacter and anti-GM(1) antibodies after inoculation into C3H/HeN mice. RESULTS: We found that, although C. jejuni was not detected in 1976 swine flu vaccines, these vaccines induced anti-GM(1) antibodies in mice, as did vaccines from 1991-1992 and 2004-2005. Preliminary studies suggest that the influenza HA induces anti-GM(1) antibodies. CONCLUSIONS: Influenza vaccines contain structures that can induce anti-GM(1) antibodies after inoculation into mice. Further research into influenza vaccine components that elicit anti-ganglioside responses and the role played by these antibodies (if any) in vaccine-associated GBS is warranted.

 

 

I looked at this study trying to to verify that lysoganglioside GM1 was the same thing that I thought was being discussed in regards to PANDAS?

 

http://www.csus.edu/bios/faculty/Kirvan/Ki...JNI_article.pdf

 

Abstract

Behavioral and movement disorders may have antibody responses where mimicry and signal transduction may lead to neuropsychiatric

abnormalities. In our study, antibodies in pediatric autoimmune neuropsychiatric disorders associated with streptococci (PANDAS) reacted

with the neuronal cell surface and caudate–putamen and induced calcium–calmodulin dependent protein (CaM) kinase II activity in neuronal

cells. Depletion of serum IgG abrogated CaM kinase II cell signaling and reactivity of CSF was blocked by streptococcal antigen N-acetylbeta-

D-glucosamine (GlcNAc). Antibodies against GlcNAc in PANDAS sera were inhibited by lysoganglioside GM1. Results suggest that

antibodies from an infection may signal neuronal cells in some behavioral and movement disorders.