glutamate transmission

[kim]

I thought I would put this on a separate thread although I believe it's related to what we're discussing on the bony tumor thread.

 

Neurexin 1 is specifically believed to be involved in building glutamate synapses

and

 

In the two-fold analysis, the researchers implicated the gene neurexin 1, located on chromosome 2, as well as a swath of sequence on chromosome 11.

 

 

As these things become better known, I hope it helps to reduce confusion about why some respond to certain supplements or dietary changes, while others might not.

 

 

http://www.sciam.com/article.cfm?id=D7C80F...8C4F&page=1

 

Neurexin 1 is part of a three-member family of genes coding for proteins involved in communication between neurons. It is associated with glutamate, the neurotransmitter known to elevate neuronal activity and play a role in wiring the brain during early development. Glutamate functioning has been implicated in other syndromes involving mental retardation of which autism is often a symptom, such as fragile X syndrome and tuberous sclerosis. Neurexin 1 is specifically believed to be involved in building glutamate synapses, the links through which glutamate neurons send and receive electrical signals.

Isn't this interesting?????

 

The project also describes discoveries of sites along the chromosome where invading viruses integrate, 'fragile' regions prone to breakage, areas called 'gene jungles' and 'gene deserts', as well as primate-specific genes.[/quote]

 

There are 23 pairs of chromosomes in the human genome and each person inherits one of each set from their parents. The chromosomes encode genes that control all aspects of human development including some behavioural characteristics.

 

 

http://www.sickkids.ca/mediaroom/custom/dna_sequence.asp

www.chr7.org

 

TORONTO - Scientists at The Hospital for Sick Children (HSC) have compiled the complete DNA sequence of human chromosome 7 and decoded nearly all of the genes on this medically important portion of the human genome. The research, which involved an international collaboration of 90 scientists from 10 countries, publishes in the online version of the scientific journal Science on April 10, 2003.

 

Two years ago, a draft (or fragmented) human genome DNA sequence was published by the public Human Genome Project, and separately by Celera Genomics. To coincide with celebrations of the 50th anniversary of the discovery of the structure of DNA, the DNA sequencing phase of the Human Genome Project will be declared completed in April.

 

"In a massive study, we combined all information in public and private databases, including data generated by Celera Genomics, as well 15 years of our data and analyses to generate what we believe is the most comprehensive description of any human chromosome. Chromosome 7 is often referred to as 'Canada's chromosome' because of this country's major contribution to the mapping and identification of many important disease genes on that chromosome over many years," said the study's lead author Dr. Stephen Scherer, a senior scientist at The Hospital for Sick Children and an associate professor in the Department of Molecular and Medical Genetics at the University of Toronto (U of T).

 

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