BeeRae22 Posted December 28, 2016 Report Share Posted December 28, 2016 Dd11 was flaring- aggression, rage, OCD, etc. and we tried an antiviral- amantadine- for the first time and it actually seems to be working! Aggression and raging stopped right after beginning it and hasn't returned- it's been about a week now.... So here's the question- coincidence? Was the flare over anyway? Or is it actually working?? Keep her on it? Take her off and see what happens? I haven't researched antivirals much (we've never tried one, so all my experience has been with abx), she still on zith and Bactrim as well.... What does it mean when/if an antiviral does something?? What should I be thinking about going forward? banwh99 1 Link to comment Share on other sites More sharing options...
banwh99 Posted December 29, 2016 Report Share Posted December 29, 2016 My daughter was diagnosed PANS in Jan and put on Amantadine too. It has antiviral but also anti-inflammatory properties. We suspected viral triggers since we never found strep or other infections. It could be that your child has viral infections triggering her symptoms and/or that the Amantadine is helping with inflammation. Either or both of those scenarios would potentially reduce symptoms....killing viral infection and reducing inflammation. BeeRae22 1 Link to comment Share on other sites More sharing options...
Gpookie Posted December 29, 2016 Report Share Posted December 29, 2016 (edited) Antivirals were as effective for flares from viruses as antibiotics were for strep infections. Same for allergy meds and flares from allergy meds. We're on longterm antivirals to lower their viral load... Edited December 29, 2016 by Gpookie Link to comment Share on other sites More sharing options...
BeeRae22 Posted January 2, 2017 Author Report Share Posted January 2, 2017 Dd is still doing great on amantadine-- seeing a huge shift in her, this is the biggest and quickest and most significant response to meds that I've ever seen in her in this amount of time. So, what were we missing before? If antiviral is working, what's causing the "viral load"? I'm not really understanding and want to know if there's anything I should be doing going forward? Things to watch for? Testing to consider??? I'm afraid to say it because I'm afraid to jinx it, but I feel like she's coming back finally- maybe more than she truly has in over 3 years?!?!?!!!! Anxiety is dissipating, OCD incredibly improved, irritability almost completely gone, kindness and empathy returning, appropriate responses to upsetting situations-- a completely different kid than she was 2 weeks ago!! Obviously I'll keep her on this and not even consider rocking that boat for quite some time, but what could amantadine be hitting that zith, Bactrim, mino, etc. weren't??? LLM, would love to have you chime in if you happen to see this!!!! Happy New Year all! --feeling hopeful for the first time in a long time! <3 Link to comment Share on other sites More sharing options...
Gpookie Posted January 2, 2017 Report Share Posted January 2, 2017 My kids have a mild immune deficiency (hypogammaglobulinemia) and can't fight off infections as easy...thats why abx combo and anti virals + LD IVIG got rid of PANDAS. Link to comment Share on other sites More sharing options...
Wombat140 Posted January 2, 2017 Report Share Posted January 2, 2017 Why were you prescribed the amantadine, did she test positive for something? Curious to know what might be grounds for trying this. Link to comment Share on other sites More sharing options...
trggirl Posted January 2, 2017 Report Share Posted January 2, 2017 (edited) My daughter was also prescribed this a number of years ago, and we also had wonderful results. I read somewhere that it may effect the glutamate system. This might be why it helps?? Edited January 2, 2017 by trggirl Link to comment Share on other sites More sharing options...
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