S Pneumonia Titers - normal response?

[Sonshine]

Can those who have been diagnosed with immune deficiency, weigh in? Do post vaccination titers need to be above a certain level? I've read greater than .35, greater than 1.3 and greater than 2.0 ? If values are below that but are 2 fold or 4 fold pre-vaccination titer, is that a sufficient response? DS has had symptoms of Selective Antibody Deficiency since birth.

 

Edited February 26, 2015 by Sonshine

[Sonshine]

Also, DS shows protection for tetanus and Hep B but not varicella?

[kim]

Sonshine,

 

Have you read these threads? I think Buster has some papers on one of these threads that might be helpful?

 

http://latitudes.org/forums/index.php?showtopic=5167
http://latitudes.org/forums/index.php?showtopic=5167&page=1

PREVNAR 13

http://latitudes.org/forums/index.php?showtopic=11319

 

 

This doesn't relate to your question but it is interesting for those reading on the subject

 

http://www.ncbi.nlm.nih.gov/pubmed/15385481
Limited Role of Antibody in Clearance of Streptococcus pneumoniae in a Murine Model of Colonization

Edited February 24, 2015 by kim

[kim]

Sonshine,

 

Have you found this paper yet? It looks like this has some good infomation on the challenge vaccination results.

 

http://www.aaaai.org/Aaaai/media/MediaLibrary/PDF%20Documents/Practice%20and%20Parameters/Diagnostic-vaccination-in-PID-2012.pdf

 

Use and interpretation of diagnostic vaccination in primary

immunodeficiency: A working group report of the Basic and

Clinical Immunology Interest Section of the American

Academy of Allergy, Asthma & Immunology

this may or may not be helpful with the negative varicella result

http://www.cdc.gov/vaccines/pubs/pinkbook/varicella.html

Laboratory evidence of immunity or laboratory confirmation of disease. Commercial assays can be used to assess disease-induced immunity, but they lack adequate sensitivity to reliably detect vaccine-induced immunity (i.e., they may yield false-negative results).

 

 

 

[Sonshine]

Kim: Thank you. Just got a call that our doctor uses the criteria outlined in the paper you provided the link to. DS only had a response to 7/23 and has been referred to immunologist for further workup. I know there was an old thread about this, but I wonder how many of our kids have an underlying immune deficiency? DS has had ear infections, sinus infections, skin infections (impetigo) and pneumonias (myco P) since birth. I'm quoting others who have said "something opens the door for PANS/PANDAS.