Topical Magnesium interacting with Minocycline?

[Mayzoo]

Does anyone know if topical magnesium interacts with oral minocycline? My gut and logic say no, google does not seem to say anything (I was using my phone, but will try later on a "real computer"), but I wanted to see if anyone had a definitive answer.

 

I know the interaction is binding together, and they will not "really" be in the GI together to bind, but I ask because I know IM Toradol injectable (ketorolac) used to be sited for GI bleeding even though it was never "really" in the GI. Topical and IM clearly both can get into the GI, so I have to ask.

 

Thanks.

Edited November 24, 2014 by mayzoo

[kim]

mayzoo,

 

You may have already found this. I don't know how the time frame would work given that you are using topical. I guess I would allow extra time for absorbtion rate btwn application and minocycline dosing?

 

http://umm.edu/health/medical/altmed/supplement-interaction/possible-interactions-with-magnesium

 

Possible Interactions with: Magnesium
Interactions

If you are currently being treated with any of the following medications, you should not use magnesium without first talking to your health care provider.

Antibiotics --The absorption of quinolone antibiotics, such as ciprofloxacin (Cipro) and moxifloxacin (Avelox), tetracycline antibiotics, including tetracycline (Sumycin), doxycycline (Vibramycin), and minocycline (Minocin), and nitrofurantoin (Macrodandin), may be diminished when taking magnesium supplements. Therefore, magnesium should be taken 1 hour before or 2 hours after taking these medications to avoid interference with absorption.

 

[Mayzoo]

mayzoo,

 

You may have already found this. I don't know how the time frame would work given that you are using topical. I guess I would allow extra time for absorbtion rate btwn application and minocycline dosing?

 

http://umm.edu/health/medical/altmed/supplement-interaction/possible-interactions-with-magnesium

 

Possible Interactions with: Magnesium

Interactions

 

If you are currently being treated with any of the following medications, you should not use magnesium without first talking to your health care provider.

 

Antibiotics --The absorption of quinolone antibiotics, such as ciprofloxacin (Cipro) and moxifloxacin (Avelox), tetracycline antibiotics, including tetracycline (Sumycin), doxycycline (Vibramycin), and minocycline (Minocin), and nitrofurantoin (Macrodandin), may be diminished when taking magnesium supplements. Therefore, magnesium should be taken 1 hour before or 2 hours after taking these medications to avoid interference with absorption.

 

 

Yes, oral magnesium and oral cyclines is a big no no. Magnesium needs to be 2 hours before or 4 hours after minocycline.

 

I cannot find any literature that addresses an interaction warning on topical (or injectable) magnesium and oral cyclines. I have even tried google scholar and nothing .

 

For now, I am going to assume the oral restrictions apply just to be safe. I am hoping someone knows for sure, and I am emailing her doc to see what he says.

 

Thanks.

Edited November 24, 2014 by mayzoo

[kim]

That would be interesting to know mayzoo. It looks like transdermal can affect blood levels rather quickly, but I see where you're coming from i.e. blood level interactions would not be the "bind and block absorbtion," scenario.

[Mayzoo]

That would be interesting to know mayzoo. It looks like transdermal can affect blood levels rather quickly, but I see where you're coming from i.e. blood level interactions would not be the "bind and block absorbtion," scenario.

 

I am hoping the interaction does not include the transdermal . Dosing is already challenging enough around here. But, I may not get what I hope for, time will tell I hope. Until the doc responds or I find something, I will keep them separated.

[Mayzoo]

Her doc (immunologist/PANDAS specialist) just emailed back and said topical does not carry the same interaction warning as oral. That may make life a little easier .