Gastrin-releasing peptide

[kim]

I ran across this while I was looking for info. on gut flora, after my son's recent strep.

 

Many here probably know about my frustration with my youngest sons limited diet. This caught my eye

 

http://www.phoenixpeptide.com/allobesity/C...n/Bombesin.html

 

We conclude that BN-related peptides play an important role in the control of food intake, and may contribute to ingestive disruptions associated with anorexia (anorexia nervosa, AIDS and cancer anorexia), bulimia, obesity and depression. Hence, pharmacological targeting of these systems may be of therapeutic value.

 

 

Then I found info. relating to gastrin-releasing peptide or bombesin like peptides in TS, and asthma (my boys don't have asthma, but Dr.s have treated them with albuterol, and other asthma like meds. for respiratory illness)

 

Just thought others might find this interesting.

 

http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=137580

 

In linkage studies of 25 families, Comings et al. (1986) found no linkage but observed a family in which 6 members with various manifestations of Tourette syndrome carried a balanced translocation, t(7;18)(q22;q22.1). Linkage to a COL1A2 RFLP was excluded, suggesting that the mutation is on chromosome 18. They noted with interest the assignment of the gene for gastrin-releasing peptide (bombesin; 137260) and pointed to this as a candidate for the site of the mutation in Tourette syndrome. They stated that injection of bombesin 'into the brains of mice reproduce many of the symptoms of Tourette syndrome.' Donnai (1987) presented further evidence for the location of the Tourette gene at 18q22.1; deletion at this site was found in a 23-year-old woman who 'had the behavioral characteristics described in members of Tourette families.

 

 

http://www.biology-online.org/dictionary/G...leasing_peptide

 

gastrin-releasing peptide

(Science: hormone) a regulatory peptide (27 amino acids) thought to be the mammalian equivalent of bombesin. It elicits gastrin release and regulates gastric acid secretion and motor function.

 

It causes bronchoconstriction and vasodilation in the respiratory tract and stimulates the growth and mitogenesis of cells in culture. once released from nerves in the antrum of the stomach, the neuropeptide stimulates release of gastrin from the g cells.

 

http://ajrccm.atsjournals.org/cgi/content/full/158/1/320

 

The control mechanisms for epithelial cell migration after injury remain unclear and require a deeper understanding of how agents such as BLP may be linked to the action of matrix proteins which may be concerned with cell migration such as fibronectin, insulin, transforming growth factor-A, inflammatory cytokines, and epidermal growth factor (EGF). The GRB is associated with phospholipase and is known to activate protein kinase-C (PKC) so that GRB receptor ligand interactions can involve several different signal transduction pathways, all of which require elucidation.