CYP2D6 Snip on Genetic Genie Detox Profile

[Rachel]

I found an article by St. Jude Children's Research Hospital that talks about this gene and there is an enyzme test that also checks for drug response. This gene showed up on my son's Detox Profile. However, I am confused because this article does not mention the varations of this gene but I am wondering if this is the reason why my son does not respond to pain medications. The gene CYP2D6 S486T showed +/+, CYP2D6 100>T +/- and CYP2D6 2850C>T was +/- on my son's Detox Profile. Could this mean that my son might have a problem with metabolizing certain medications? I have sent this information to my son's doctor but was wondering if anyone else was dealing with this possible problem.

 

http://www.stjude.org/stjude/v/index.jsp?vgnextoid=4d00b53d06550310VgnVCM1000001e0215acRCRD

 

 

[TeamTyrion]

Hi rachel,

My ds is also CYP2D6 positive (++ on both the S486T and T100C). I checked out your link - thanks for the reference.

 

"Could this mean that my son might have a problem with metabolizing certain medications?" - To answer, YES! Definitely.

 

Here is another link that I printed out, just in case someday I should need a full list of drugs that may be implicated:

http://en.wikipedia.org/wiki/CYP2D6

 

Scroll to the bottom for the list. There are psychiatric drugs in there apparently.

 

There's a lot of info out there on codeine and how it's definitely not advised for those with the CYP2D6 polymorphism: http://www.nps.org.au/health-professionals/health-news-evidence/2013/codeine-children-safety-warning

Edited July 31, 2014 by teamtyrion

[Rachel]

Thanks for sending that last article. If I give my son codeine, it makes his vocal tic worse.

 

Is there any way to switch this gene off?

[TeamTyrion]

I don't know. I guess the question is, once a gene starts expressing, can it ever stop expressing? Hmm, perhaps LLM can chime in on that one.