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Article by Psychiatrist turned MD on Brain Inflammation/macrophages


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This is a fascinating article by Mary Ackerley, M.D. which plainly discusses the brain/depresssion/macrophages. At the end there are recommended treatments: Vitamin D, fish oil, probiotics, magnesium, turmeric, and of course, diet.

 

 

http://paradigmchange.me/wp/?p=596

 

Here is just one section of the article:

 

"Hypothalamic-Pituitary Axis

Here’s some more basic science about what we are looking for in the brain when we talk about inflammation. This is a diagram of your brain. It’s looking at your hypothalamus and pituitary.

Stress-Pathway-300x280.jpgWhen you look at Dr. Shoemaker’s model, he’s going to start with damage in the hypothalamic-pituitary axis. It’s that damage that leads to the decrease in hormones that we often see — the decrease in androgens, the decrease in cortisol. Sometimes, as Dr. Shoemaker will say, you’ll see an increase in cortisol, which is your body’s last fling at trying to correct things before you sink into the decreasing cortisol.

This diagram shows the relationship between cortisol and brain inflammation and the cascade of events that happen subsequent to stress.

In this diagram it’s labeled as stress. Stress can be from many different things, such as interpersonal difficulties.

Early adversity is something that is well-studied in psychiatry. Having abusive childhoods is very common, more common than anyone would like to think. This will lead to changes in our ability to secrete cortisol.

This leads to changes in cytokines of something called Nuclear Factor Kappa Beta. It flourishes. That increases inflammation in the body.

The inflammation in the body leads to excitotoxicity. That’s another word for anxiety, really. It decreases neurotransmitters and also causes depression.

There are several agents that can cause this kind of depression besides stress. Biotoxins would be big ones. Others would be heavy metals, food allergens and viruses."

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Will be good to hear your experiences!

 

Just shared my personal notes and info. on gcmaf with my son's other MD (not the one who prescribed it). She is very interested for herself and patients.

 

So far the biggest change from the treatment for my son are the viral symptoms that have abated at last. This is huge after trying for almost 4 years to get rid of them.

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