OCD Reduction and Culturelle / Lactobacillus rhamnosus GG Probiotic

[TOaksMom]

I also posted this on the PANS/PANDAS forum: http://latitudes.org/forums/index.php?showtopic=22272

 

 

There is a new Feb. 2014 study from Lehigh University in Pennsylvania: (http://www.ncbi.nlm....pubmed/24257436) that says:

 

"Two experiments examined probiotic pretreatment (Lactobacillus rhamnosus GG) on obsessive-compulsive disorder (OCD)-like behavior induction by RU 24969 in BALB/cJ house mice. In the first experiment, two groups were defined by their daily pretreatment by oral gavage of either (a) L. rhamnosus (1×10⁹ CFU/day) or b. the saline vehicle. Both a 2- and 4-week probiotic pretreatment attenuated OCD-like behavior induction (increased perseverative open-field locomotion, stereotypic turning, and marble burying) relative to saline pretreatment. Experiment 2 re-examined the 2-week probiotic pretreatment while also comparing it to a 4-week fluoxetine pretreatment. Again, groups were defined by daily pretreatment of either (a) L. rhamnosus for 2 week, b. the saline vehicle for 2 weeks, or c. fluoxetine (10 mg/kg) for 4 weeks. Pretreatment by either L. rhamnosus or fluoxetine blocked the induction of OCD-like behavior compared with saline pretreatment. Thus the 2-week probiotic pretreatment was again effective. Although side effects of fluoxetine or L. rhamnosus on androgen-dependent behaviors could not be demonstrated, L. rhamnosus treatment appeared comparable to fluoxetine treatment in attenuating mouse OCD-like behaviors."

 

Lactobacillus rhamnosus GG is Culturelle:

Generic Name: lactobacillus rhamnosus GG

Brand Name: Culturelle DS, Culturelle HS

http://www.drugs.com...turelle-ds.html

https://web.archive....relle_vs_others

 

Lactobacillus rhamnosus GG appears to only be sold as Culturelle in the US:

 

Lactobacillus rhamnosus GG (ATCC 53103) is a strain of L. rhamnosus isolated in 1983 from the intestinal tract of a healthy human being; filed for patent on 17 April 1985, by Sherwood Gorbach and Barry Goldin.[2] (The 'GG' derives from the first letters of their surnames').[3] The patent refers to a strain of "L. acidophilus GG" with American Type Culture Collection (ATCC) Accession No. 53103; later reclassified as a strain of L. rhamnosus. The patent claims the L. rhamnosus GG (ATCC 53103) strain is acid– and bile–stable, has a great avidity for human intestinal mucosal cells, and produces lactic acid. In 1990, Finnish company Valio launched Valio Gefilus, a family of products containing Lactobacillus rhamnosus GG (ATCC 53103), for which they also use the trademark LGG.[24] Valio has licenced rights to LGG to several companies, including Amerifit Brands in the United States (Culturelle), FrieslandCampina in the Netherlands (Vifit),[25] Oriola in Finland (Gefilus and LGG), and Dukat in Croatia (LGG).

 

 

[searching_for_help]

Interesting. My dd OATS test from The Great Plains Laboratory showed high HPHPA ((3-(3-hydroxyphenyl)-3-hydroxypropionic acid). The interpretation said it is "associated with behavioral, GI, and/or neuropsychiatric effects. It is an abnormal phenylalanine metabolite produced by GI bacteria of the Clostridia genus, including C. sporogenes, C. botulinum, C. caloritolerans, C. mangenoti, C. ghoni, C. bifermentans, C. difficile, and C. sordelli." (GI symptoms may include diarrhea or constipation.)

 

So the interesting part: "In most cases, Clostridia overgrowth can be controlled by probiotics supplementation, with 30 billion cfu's/day or more of Lactobacillus rhamnosus GG (Culturelle) and/or at least 2-6 billion cfu's/day of Saccharomyces boulardii."

 

So, with toaksmoms info, and this info, it leads me to think some OCD is caused by Clostridia. My daughter does not have the markers for C. Diff - but she does have the high markers for one or some of the other clostridia - and she has OCD and intrusive thoughts (among other things...) Once again, it looks like the gut is a major player.

Edited February 9, 2014 by searching_for_help