gut

[pr40]

I am having post antibiotic problems with my gut and did some research and thought I'd share this piece of info, believing you all might find it interesting if you don't know it already.

it's from wikipedia

"Drugs affecting serotonin (5-HT) in the intestines can help reduce symptoms.^[90] 5HT3 antagonists such as ondansetron are effective in postinfectious IBS and diarrhoea-dominant IBS due to their blockade of serotonin on 5HT3 receptors in the gut; the reason for their benefit is believed to be that excessive serotonin in the gut is believed to play a role in the pathogenesis of some subtypes of IBS. Benefits may include reduced diarrhoea, reduced abdominal cramps, and improved general well-being. Any nausea present may also respond to 5HT3 antagonists owing to their antiemetic properties.^[91] Serotonin stimulates the gut motility and so agonists can help constipation-predominate irritable bowel, while antagonists can help diarrhea-predominant irritable bowel. Selective serotonin re-uptake inhibitors, SSRIs, frequently prescribed for panic and/or anxiety disorder and depression, affect serotonin in the gut as well as the brain. The bowels are highly dependent on serotonin for neural communication. "Selective serotonin re-uptake inhibitor antidepressants seem to promote global well-being in some patients with irritable bowel syndrome and, possibly, some improvement in abdominal pain and bowel symptoms, but this effect appears to be independent of improved depression. Further research is required."^[92]

[qannie47]

I just love this forum. It has provided so many "OPRAH AHA MOMENTS". My ds, whom is non-pandas, his brothers twin has had a long history of stomach pains and constipation. It just so happens that he is a little on the adhd side of the fence, and can be irritable. About 3 months ago, I started giving him 5HTP. It has helped his focus and temperament in a pretty big way. Amazingly, 80% of his stomach and bowel issues have disappeared along with his improvement. I never made the connection. Very interesting indeed.

 

The 5htp had no impact what so ever on my Pandas child, which is whom I bought it for in the first place.

[searching_for_help]

Thanks for sharing this info. My daughter's gut is a mess, I'm assuming it started early on when she was young and having lots of strep issues. I find this all so difficult to figure out, because my daughter has all the symptoms of very low serotonin, so she was put on a low dose of Luvox (fluvoxamine), yet when we had her neurotransmitters tested, she is off the charts HIGH in serotonin! (Dangerously so...) It's like she's unable to utilize it properly,(maybe not enough receptors to use it all?) so we are backing off of her dose slowly, and going to eliminate the SSRI entirely. It was quite a shock, and certainly none of her results have been what we've expected, so sadly been treating incorrectly.

 

Everyone is different (that's what makes all of this so difficult!). The answer to all of this is getting the gut back in shape so it can do it's job with the neurotransmitters and absorb our nutrients properly. (I know B12 plays a role in serotonin...) Sadly, getting the gut back working properly is the HARD part! But SSRI's might be a handy bandage for some, until they can get their gut health back in shape - I just wanted to point out that it isn't for all.

 

Source Naturals makes a Coenzymate B Complex that is sublingusl that goes directly into the bloodstream (bypassing the bad gut), and a deficiency in B vitamins (especially B12) is associated with mood disorders. This is a good (short)article about B12, omega 3's and SSRI's. Sounds like taking a B supplement (sublingual in my opinion) can even help the SSRI do it's job more affectively, for people that want to go that route.

 

http://www.livestrong.com/article/528436-vitamin-b12-ssris/