qannie47 Posted July 30, 2013 Report Share Posted July 30, 2013 Hi everybody. Well, my ds7 is about 8 weeks post IVIG. I have journal his progress. Breaking it down: First 3 weeks: asymptomatic w/exception of bedwetting which ended in 3rd week. Since then: 3 severe days of symptoms: 2 back to back and then 1 day and then gone. Awakened completely calm following mornings. 4 days of moderate couple of hours to 1/2 day of symptoms then a calming down was apparent. The rest of the days have been comprised of 40% residual behavior issues (able to respond to behavior mgmt. program in place) & the rest of the days...Pretty darn good!!! One symptom that my ds has never showed on any grand scale was separation anxiety since he has a twin...However, this has cropped up over the last 3 days and is the current only symptom. I find this curious...why now? And...why do they consider this wax/waning a part of the healing? Any Ideas???? Link to comment Share on other sites More sharing options...
LaurenK Posted July 30, 2013 Report Share Posted July 30, 2013 (edited) I think that there are a lot of different theories on this, I'll go ahead and name some: 1) After IVIG, your body can develop immune complexes 2) The donor antibodies are getting at some sort of intra-cellular bacteria and causing a die-off reaction 3) You liver gets sort of overwhelmed with all the bad antibodies that the good ones are destroying 4) Problem behavior might be a chronic infection such as Lyme or mycoplasma- it may not be an up and down at all. Most of it, I think relates back to the detoxification pathways in the body being blocked up. Those are the main ones that I have heard. In terms of how IVIG works, there are several different theories on that as well. Some say that it resets the immune system, others say that it simply modulates the immune response, others say it gets rid of chronic infections, and a newer one that I've heard is that the donor antibodies prevent the bad ones from doing damage once inside the basal ganglia....something about mglur1. I'll have to go back and ask my neurologist this. Edited July 30, 2013 by LaurenK Link to comment Share on other sites More sharing options...
qannie47 Posted July 31, 2013 Author Report Share Posted July 31, 2013 Thank you so much for your very informative reply...very helpful! Link to comment Share on other sites More sharing options...
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