Hopeny Posted March 22, 2013 Report Share Posted March 22, 2013 (edited) the study link below found that Bb uses Manganese not Iron (every other bacterium/virus uses iron) to reproduce. then I found this in wikipedia in regards to overproduction. I just checked DD's results and her Manganese was closer to the high end of the range (26 with a top end of 33). Wondering if Lyme induced overproduction of Manganese could lead to the neurodegenerative impact of Lyme...Wondering if there is anything to reduce Manganese in the body? or is that advisable? Does anyone have any information on this? Has anyone had their kids levels tested and if yes what were they? "Neurodegenerative diseases Chronic low-dose manganese intoxication is strongly implicated in a number of neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. It may also play a role in the development of multiple sclerosis, restless leg syndrome, and Huntington's disease. A protein called DMT1 is the major transporter involved in manganese absorption from the intestine, and may be the major transporter of manganese across the blood–brain barrier. DMT1 also transports inhaled manganese across the nasal epithelium. The putative mechanism of action is that manganese overexposure and/or dysregulation leads to oxidative stress, mitochondrial dysfunction, glutamate-mediated excitoxicity, and aggregates of protein." http://www.eurekalert.org/pub_releases/2013-03/whoi-srq032113.php Note this is manganese, I believe its different from magnesium Edited March 22, 2013 by Hopeny Link to comment Share on other sites More sharing options...
nicklemama Posted March 23, 2013 Report Share Posted March 23, 2013 I find that very interesting. Ill have to look up DS' manganese levels. He is very deficient in iron and his new doc is having me supplement. Link to comment Share on other sites More sharing options...
Hopeny Posted March 23, 2013 Author Report Share Posted March 23, 2013 Please let me know when you find out the level. It will be interesting of we notice any trends with kids with Lyme, especially in regards to what levels are when kids are very sick and what they are in recovery, what they are on abx and what they are iff. My dd is not fully well but pretty close. It's hard to know what lurks of course Link to comment Share on other sites More sharing options...
nicklemama Posted March 23, 2013 Report Share Posted March 23, 2013 Manganese levels are right in the middle of the normal range. Ferritin levels low and have been for three yrs. He does not have a Lyme dx at this time, just coinfections. Hmmmm Link to comment Share on other sites More sharing options...
SSS Posted March 23, 2013 Report Share Posted March 23, 2013 I found this very interesting- my take on it is that the Lyme bacteria uses up all the manganese - not the iron as previously thought, although my understanding is Babesia uses up iron- Some years ago, I was studying Andrew Cutler chelation protocol for heavy metals, and did the Doctors Data hair tests on dd and myself- The hair tests show what minerals are excreting, and heavy metals (mercury, lead, etc.). Cutler also had a formula to look at mineral derangement on the hair test results. Anyway, my test came back 'normal' (I never had amalgams, vaccines, etc.) Except, I showed ZERO manganese! And low magnesium. It suggested I start supplementing manganese immediately. Link to comment Share on other sites More sharing options...
nicklemama Posted March 23, 2013 Report Share Posted March 23, 2013 Very interesting. Yes, I thought the implication is low levels because of the use of the metal. We suspect DS also has babesia due to his symptoms. The test came back negative but he will be treated for babesia after the ehrlichia treatment. Link to comment Share on other sites More sharing options...
Suzan Posted March 24, 2013 Report Share Posted March 24, 2013 My dd11 tests low for Manganese and takes it daily now. Interesting..... Link to comment Share on other sites More sharing options...
Hopeny Posted March 25, 2013 Author Report Share Posted March 25, 2013 Initially I 'was thinking that maybe Bb could cause overproduction . Now I am thinking maybe the opposite. I wondering if this means Lyme is no longer a factor for dd Link to comment Share on other sites More sharing options...
rowingmom Posted March 25, 2013 Report Share Posted March 25, 2013 Initially I 'was thinking that maybe Bb could cause overproduction . Now I am thinking maybe the opposite. I wondering if this means Lyme is no longer a factor for dd Sorry, but I really don't understand the concept that Bb can produce manganese. Manganese is a trace mineral and you shouldn't have high levels unless you are oversupplementing, or being poisoned in some way. Do you perhaps mean that Bb could have sequestered manganese and that high levels were released with die-off? We have never tested for manganese, iron levels are normal. Link to comment Share on other sites More sharing options...
Hopeny Posted March 28, 2013 Author Report Share Posted March 28, 2013 Rowingmom I was wondering along the laws of supply and demand, if Bb started to demand/use Manganese could that in turn lead to signals being set off to overproduce?? My kids have an immune problem and essentially they get infiltrated with bacteria/virus which leads to an overactive immune response, more than normal. I was wondering if this could happen with manganese, but it seems like people have a low level/depleted. Since my Dd's levels is towards the higher end, I am now wondering if we are no longer dealing with Bb? I just wish we had had her level tested when we started treating so I would have a baseline. It's interesting stuff. Link to comment Share on other sites More sharing options...
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