CVID and IVIG

[mdmom]

For those of you who have children getting IVIG for CVID or another primary immune deficiency, how low were your children's total IGG levels when they were diagnosed?

 

Just curious....

[landamom]

Our daughters total IgG was 460, her subclass 1 is in the 200s and subclass 2 is in the 90s we are awaiting preapproval for IvIg. Not holding out of much hope though because I worry they will want to do a vaccine challenge and I don't want to risk that. What are your levels?

[thenmama]

landamom, I don't know what insurance carrier you have, but I'm pretty sure your child would qualify for coverage for IVIG on the BCBS guideline used in our region. They cover with a total IgG below 500 for CVID dx. For Subclass deficiency the criteria is > 2 standard deviations below the lower limits of normal, plus failed vax challenge, plus recurrent infections. It's frustrating that companies are allowed to make guidelines with such arbitrary cutoffs, since docs say it's the function that means most, not whether you fall two points below some number or two points above.

[Hayley]

My daughter is 7 and her IgG was 392 adn IgA 12. When we tested again a month later, the IgG was around the same (within a couple of points) but IgA went up to 23.