melanie Posted August 30, 2012 Report Posted August 30, 2012 I want to add the NAC back into dans life. Does anyone remember the dosage recommended for OCD from the nimh?
MomWithOCDSon Posted August 30, 2012 Report Posted August 30, 2012 Danny's over 90 pounds, right? Then it would be the adult dose of 3,000 mg. per day. Ours come in 600 mg. capsules, so we do 1,800 mg. morning and another 1,200 mg. at night. Start low and titer up, though, because it can cause some gastro discomfort if you give too much, too quickly. Good luck!
melanie Posted August 30, 2012 Author Report Posted August 30, 2012 Dans 150 lbs. Ours is 750 mg. So I've been giving him 1 at night for 3 days. Should I increase to 1 am 1 pm. He is taking depakote. ( I know) too and minocycline
MomWithOCDSon Posted August 30, 2012 Report Posted August 30, 2012 On 8/30/2012 at 9:17 PM, melanie said: Dans 150 lbs. Ours is 750 mg. So I've been giving him 1 at night for 3 days. Should I increase to 1 am 1 pm. He is taking depakote. ( I know) too and minocycline Melanie -- You probably ought to run your questions past a knowledgable pharmacist and/or Danny's doctor because I don't know what possible interactions, if any, you might run into with those meds. All I know is that you have to be mindful of NAC dose alongside any serotonin-impacting meds or supplements (like SSRIs, St. John's Wort, inositol, SamE, etc.) because it impacts serotonin availability, also and you don't want to overdose that. Sorry not more help!
beeskneesmommy Posted August 31, 2012 Report Posted August 31, 2012 Please tell me what is NAC? Thanx
MomWithOCDSon Posted August 31, 2012 Report Posted August 31, 2012 On 8/31/2012 at 12:45 PM, Beeskneesmommy said: Please tell me what is NAC? Thanx N-acetylceisteine, a naturally-occuring amino acid that can help control excess brain glutamate which is thought to be at least one culprit in OCD, anxiety, etc. It's inexpensive and easily available over the counter at places like Whole Foods and The Vitamin Shoppe, plus it's been studied for its effectiveness. Anecdotally, some kids seem to respond well to it, but others don't. If you search for the term (NAC) on the forum, you'll come up with at least a half-dozen threads. I just Googled it again and came up with what, to me at least, is a new paper on the topic: NAC in Psychiatry
melanie Posted September 1, 2012 Author Report Posted September 1, 2012 It doesn't say the dosage for OCD. Ughhh. He's up to 1500 mg. Let you know. Thanks OCD mom. Knew I could count on you
MomWithOCDSon Posted September 1, 2012 Report Posted September 1, 2012 On 9/1/2012 at 11:18 AM, melanie said: It doesn't say the dosage for OCD. Ughhh. He's up to 1500 mg. Let you know. Thanks OCD mom. Knew I could count on you Melanie -- The only "dosage information" I've ever seen came from these two NIMH/Yale trials: one for kids and one for adults. This was our guideline for the 3,000 mg. dose for our now 155 lb, 15yo DS. Here's the trial paper for adults: NAC in Adult OCD Here's the trial paper for kids: NAC for Pediatric OCD
melanie Posted September 1, 2012 Author Report Posted September 1, 2012 Nancy. I read the study. It said it was cancelled. I remember reading one a year or so ago. Thought there were results?
MomWithOCDSon Posted September 1, 2012 Report Posted September 1, 2012 Sorry, Melanie. I wasn't following . . . I'm flying too fast? I thought you were wondering about dosage. I'm not sure about the various studies, results, cancellations, etc. I'll have to go back and read what I have in my library again myself. Thanks for the heads up!
melanie Posted September 3, 2012 Author Report Posted September 3, 2012 Thanks I know I read this. I'm sticking with it right now. He seems very happy. I'll take it . Have him on 2250
EAMom Posted September 4, 2012 Report Posted September 4, 2012 (edited) On 9/3/2012 at 7:08 PM, melanie said: Thanks I know I read this. I'm sticking with it right now. He seems very happy. I'll take it . Have him on 2250 here's paper where NAC is mentioned. http://www.primarypsychiatry.com/aspx/articledetail.aspx?articleid=645 (click on "download PDF" to read it easier) They mention other glutamate modulators, there is a chart on page 73. On the bottom of page 72 there is a graph with riluzole (another glutamate modulator) and it looks like it took about 8 weeks for the full effect. So, I would assume the same might be true of NAC, it might take 6-8 weeks to "kick in" fully. Edited September 4, 2012 by EAMom
melanie Posted September 4, 2012 Author Report Posted September 4, 2012 It's not that one but wow that wasvgreat too. Thanks.
norcalmom Posted September 5, 2012 Report Posted September 5, 2012 I think the original study that was done, the one that is reference most, is the on on trichotillomania (hair pulling). I did a quick search and found a journal article about it - completed in 2009. Here is a quote on the dosage: _______________________________ Investigators performed a double-blind, placebo-controlled study of NAC treatment for trichotillomania. Fifty patients, aged 18 to 65, with a primary diagnosis of trichotillomania were randomized to receive 1200 mg NAC or placebo every day for 6 weeks. At week 6, if trichotillomania persisted, the dose was increased to 2400 mg/day or a matching increase in placebo pills; 88% of the placebo group and 72% of the treatment group received the dose increase. Patients were evaluated every 3 weeks for 12 weeks; 88% of both groups completed the study. here is whole article: http://dermatology.jwatch.org/cgi/content/full/2009/1113/3
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