Haven't posted for sometime...PANDAS symptom resurgence in both gi

[AmySLP]

My 7 yr old has been symptom free for over 6 months with daily prophylaxis, but her prior tics in one extremity (exactly the same as all other exacerbations) resumed. Prior to this, she's battled this for 3 years. And her oldest OCD behavior is back as well, beginning 3 days ago. She tested negative to strep which I believe in due to the daily prophylaxis. My 5 year old tested positive however. We have always been on the fence about her, as her symptoms have always been behavioral-emotional lability and rages. She's also had increased urinary frequency. In the past dr. B dx. Her with PANDAS...we've always questioned it, but these were her only symptoms beginning a few days ago. Positive on rapid. I have an excellent ped. who agrees that those are her PANDAS symptoms and that the dx. Is accurate. We finally see it too. My question is where I can find the theory behind the response to the strep in my older daughter in the absence of infection, but in the presence of strep in the house.

 

Thanks,

Amy

[LNN]

One theory is that the non-sick child's immune system reacts to the perceived threat and arms for war, despite no active infection. Instead of attacking strep, it attacks self. I know others can give you a better explanation than that.

 

My personal theory is that your body needs a certain level of nutrients to function normally. When you get sick, those nutrients are diverted toward pathways that fight infection or potential invasion. That leaves other pathways depleted and produces symptoms. If you hover at borderline deficiency on, lets say zinc or C, and then your body needs extra for the immune system, then you crash into a red zone. You need 120% but only have 80%, creating a 40% gap. But that's my theory only, gathered from all my methylation research. It's not the one I've heard from Pandas docs.

[airial95]

I can relate on several fronts, first, my dd5 was confirmed pandas by dr. M in jan, her symptoms were very mild emotional lability being the biggest, until this most recent infection - its been very clear cut. As for exposure, my very severe pandas son jumps every time. I agree with Amy, the way it's explained to me, since it's the antibodies that cause the problems, if the body is exposed, the immune system attacks..hence the problem.

 

In our case, that flare usually lasts 4-6 days, and subsides...so I would see what happens

[tpotter]

My 7 yr old has been symptom free for over 6 months with daily prophylaxis, but her prior tics in one extremity (exactly the same as all other exacerbations) resumed. Prior to this, she's battled this for 3 years. And her oldest OCD behavior is back as well, beginning 3 days ago. She tested negative to strep which I believe in due to the daily prophylaxis. My 5 year old tested positive however. We have always been on the fence about her, as her symptoms have always been behavioral-emotional lability and rages. She's also had increased urinary frequency. In the past dr. B dx. Her with PANDAS...we've always questioned it, but these were her only symptoms beginning a few days ago. Positive on rapid. I have an excellent ped. who agrees that those are her PANDAS symptoms and that the dx. Is accurate. We finally see it too. My question is where I can find the theory behind the response to the strep in my older daughter in the absence of infection, but in the presence of strep in the house.

 

Thanks,

Amy

 

 

She only needs microbial exposure to get increase in symptoms.