Complement deficiency?

[missionmom]

Darn, found this thread without enough time to finish before getting ready for work! Always more info on the horizon. Thanks for keeping it coming, although I am again in a tailspin of indecision

[missionmom]

You guys are 5 steps ahead of me!

 

Pandas suspect (still not official dx) DS with immuno def's complement test just arrived last night. Performed by RDL Reference Lab (I understand there are different "normals" for diff. labs).

 

Anti - Nuclear AB Positive

ANA Titer 1:80

ANA Pattern Speckled All those are considered abnormal results and indicate a possible autoimmune disorder (SLE mostly)

 

C3 Complement 104 (normal listed as 79 - 152) OK

C4 Complement 13 (normal listed as 16 - 47) LOW

 

 

All other tests showed OK. Handwritten note says "no conclusive evidence of autoimmune condition".

 

I joined some of you in the rabbit hole last night attempting to research what these results mean and how they might influence the vaccination issue. I am simply baffled at this point. Feel like retreating back into my " alternative medicine" only, but I really want to be well-informed and consider all avenues. I don't want to make a decision from "baffled".

[kim]

missionmom,

 

Would you be willing to do IVIG at this point? In other words, if he doesn't show a good response what would you do about it?

 

Do you know what your sons IgG subclasses are?

 

I don't want to appear that I have any knowledge here. I'm just learning as I go too.

 

The reason that I ask the subclass question...

 

http://emedicine.medscape.com/article/885348-overview#a0104

 

excerpt

 

http://emedicine.medscape.com/article/885348-overview#a0104

 

Antibodies against pneumococcal polysaccharide antigens are predominantly IgG2 and, to a lesser degree, IgG4. In contrast, antibodies against protein antigens, such as tetanus, are predominantly IgG1 and, to a lesser degree, IgG3. Finally, antibodies against large extracellular parasites, such as Schistosoma and Filaria organisms, exclusively belong to IgG4 subclass.[3]

[missionmom]

missionmom,

 

Would you be willing to do IVIG at this point? In other words, if he doesn't show a good response what would you do about it?

 

Do you know what your sons IgG subclasses are?

 

I don't want to appear that I have any knowledge here. I'm just learning as I go too.

 

The reason that I ask the subclass question...

 

http://emedicine.medscape.com/article/885348-overview#a0104

 

excerpt

 

http://emedicine.medscape.com/article/885348-overview#a0104

 

Antibodies against pneumococcal polysaccharide antigens are predominantly IgG2 and, to a lesser degree, IgG4. In contrast, antibodies against protein antigens, such as tetanus, are predominantly IgG1 and, to a lesser degree, IgG3. Finally, antibodies against large extracellular parasites, such as Schistosoma and Filaria organisms, exclusively belong to IgG4 subclass.[3]

 

These are DS #1 results. DS #2's are even lower. I tested very high IGM and low IGA. DS #3 not yet tested.

IGG 1 396 382-929 mg/dL

IGG 2 153 241-700 mg/dL L

IGG 3 32 22-178 mg/dL

IGG 4 3.9 4-86 mg/dL L

IGG, Serum 636 694-1618 mg/dL L

IGM

Result Date: 2/1/2012

Select Component Your Value Standard Range Flag

Fasting Status

IgM 31 48-312 mg/dL L