What would you do with a 1:320 on an HHV-6 IgG?

[problemsolver]

Reference range is <1:80...

so how high is 1:320?

And, what would you want to know next?

[Ozimum]

Sorry I can't really answer your question...but have you found this website?

 

http://www.hhv-6foundation.org/testing.htm

 

"Elevated IgG antibody levels. Elevated IgG antibody levels can suggest, but not prove active, chronic infection. In a 1996 study of HHV-6 in CFS patients, 89% of the patients with IgG titers of 1:320 and above were found to have active infections by culture. (Wagner, Journal of Chronic Fatigue Syndrome)Stanford infectious disease specialist Jose Montoya believes that the best evidence of smoldering central nervous system (CNS) infection is the IgG antibody to the virus, and not the virus itself. In a pilot study, he found that when patients with high titers of HHV-6 IgG (1:320, 1:640 or higher) and EBV are treated with a potent antiviral; their titers fall substantially along with a significant improvement in symptoms.5 Elevated IgG Antibodies to HHV-6 cannot tell you for certain that the infection is active, but high titers support a clinical diagnosis. Similarly, elevated EBV VCA (late antibody) titers cannot indicate with certainly that an infection is active. However, EBV Early Antigen (EA) antibodies disappear rapidly after an infection is over, so elevated EBV EA antibodies do predict active infection."

Edited June 15, 2011 by Ozimum

[smartyjones]

what is your dr suggesting to do?

 

i am definitely concerned that viruses may be an important part of the PITAND/MCIS puzzle. i believe there is a member who may have switched to the lyme board who had a daughter that was on antivirals for hhv-6. you may want to post there to see if you can get an answer if you don't get much here.

[problemsolver]

Ozimum, you gave me more information in this paragraph than my doctor did,

and more than I've been able to find during the last 2 years of trying to get

a sensible answer to this question.

Thank you!

Dave

Sorry I can't really answer your question...but have you found this website?

 

http://www.hhv-6foundation.org/testing.htm

 

"Elevated IgG antibody levels. Elevated IgG antibody levels can suggest, but not prove active, chronic infection. In a 1996 study of HHV-6 in CFS patients, 89% of the patients with IgG titers of 1:320 and above were found to have active infections by culture. (Wagner, Journal of Chronic Fatigue Syndrome)Stanford infectious disease specialist Jose Montoya believes that the best evidence of smoldering central nervous system (CNS) infection is the IgG antibody to the virus, and not the virus itself. In a pilot study, he found that when patients with high titers of HHV-6 IgG (1:320, 1:640 or higher) and EBV are treated with a potent antiviral; their titers fall substantially along with a significant improvement in symptoms.5 Elevated IgG Antibodies to HHV-6 cannot tell you for certain that the infection is active, but high titers support a clinical diagnosis. Similarly, elevated EBV VCA (late antibody) titers cannot indicate with certainly that an infection is active. However, EBV Early Antigen (EA) antibodies disappear rapidly after an infection is over, so elevated EBV EA antibodies do predict active infection."