Primary Immune Deficiency

[butterflymom]

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Edited October 5, 2015 by tampicc

[kimballot]

Does PID develop after a child has had PANDAS for a few years? What is the thinking behind this? Is it then curable, or is the child dependent on regular IVIG?

 

 

Other folks on this forum can likely answer your questions better than I, as I, too, have a child who had "normal" titers until very recently and I am struggling to understand this as well. As I have pulled his medical record together I am seeing that IGG started dropping below protective levels around age 10, and IGA started dropping at age 13. I am told this is still considered PID because it is something he was born with - not something that is caused by HIV or another illness. I have been told that PID can change over time and that the body can slow down its production of antibodies as the child gets older.

 

I found this online information helpful - perhaps you will tool http://www.primaryimmune.org/publications/book_pats/book_pats.htm

[Guest pandas16]

Diagnosed with PANDAS age 10- Checked immunodeficiencies Age 22- None.

This is just an opinion but it seems like PANDAS kids have either an over active immune system or an under active one. Mine is over active. I have an IgE twice that of normal..but I rarely get sick..

[Phasmid]

Just to clarify, IgE is the the antibody that responds to allergens, not really pathogens such as bacteria.

[norcalmom]

I don't know if you can make a causal relationship - it seems like a chicken/egg scenario until there is a study - but certainly seems that a high percentage of pandas kids have other immune deficiencies, or develop them as they age. Either the def. make them more vulnerable to pandas, or the immune condition that causes pandas can lead to more immune disorders. At least this seems true for a bunch of our kids.

[Guest pandas16]

Just to clarify, IgE is the the antibody that responds to allergens, not really pathogens such as bacteria.

 

Yes- but it still shows some sort of immune hyper activity if my IgE is double that of normal I think.

[amyjoy]

I believe that the definition of Primary immunodeficiency is that it is inborn, rather than developed. Otherwise it would be secondary immunodeficiency.

[butterflymom]

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Edited October 5, 2015 by tampicc