Son's response to abx

[VickyLH]

Good afternoon everyone,

 

I've been a little puzzled by my son's response to abx. First a little history, he was diagnosed with a skin strep infection last June and soon after we saw a steady progression of PANDAS symptoms. His symptoms worsened considerably in December just prior to a confirmed strep throat infection during Christmas (everyone in the house had it too). He was initially prescribed Amoxicillin and had a somewhat positive reaction (more calm, stopped twirling/pulling his hair) to it after about 3 doses, however it only lasted for about 12 hours and then his symptoms worsened a little (vocal tics, saddness in addition to OCD). After a few days we switched to Augmentin and the following day he woke up feeling and acting completely like his old self again. However, once again this only lasted about 10 hours and that evening his pupils were dilated and he was extremely anxious and sad. We completed the Rx (even increased the dose a little at the end of it) and we didn't see a huge amount of improvement over the 10 days. At times he would be fine and then some time later he would have another episode that would seem to hang around for a few hours. So, this got me thinking, perhaps his skin strep infection was never fully irradicated and it went intracellular. Perhaps what we were seeing is the Amoxicillan and Augmentin quickly killing off the extracellular strep and hence providing some temporary relief, however he was continually being reinfected from cell die off and the release of intracellular strep. Does this make sense? Perhaps this is an obvious conclusion or perhaps I'm way off base with my thinking, but I'm just trying to somehow make sense of what we're seeing.

 

Today we had our first doctor's appointment with an Immunologist and we received a 30 day Rx for Azithromycin. I'm really curious if we'll see a different response since it is more effective at killing off intracellular strep... only time will tell I guess. I'll keep you posted.

 

Has anyone else seen a similar response in their child that was resolved with Azith?

 

-Vicky

[SSS]

Good afternoon everyone,

 

I've been a little puzzled by my son's response to abx. First a little history, he was diagnosed with a skin strep infection last June and soon after we saw a steady progression of PANDAS symptoms. His symptoms worsened considerably in December just prior to a confirmed strep throat infection during Christmas (everyone in the house had it too). He was initially prescribed Amoxicillin and had a somewhat positive reaction (more calm, stopped twirling/pulling his hair) to it after about 3 doses, however it only lasted for about 12 hours and then his symptoms worsened a little (vocal tics, saddness in addition to OCD). After a few days we switched to Augmentin and the following day he woke up feeling and acting completely like his old self again. However, once again this only lasted about 10 hours and that evening his pupils were dilated and he was extremely anxious and sad. We completed the Rx (even increased the dose a little at the end of it) and we didn't see a huge amount of improvement over the 10 days. At times he would be fine and then some time later he would have another episode that would seem to hang around for a few hours. So, this got me thinking, perhaps his skin strep infection was never fully irradicated and it went intracellular. Perhaps what we were seeing is the Amoxicillan and Augmentin quickly killing off the extracellular strep and hence providing some temporary relief, however he was continually being reinfected from cell die off and the release of intracellular strep. Does this make sense? Perhaps this is an obvious conclusion or perhaps I'm way off base with my thinking, but I'm just trying to somehow make sense of what we're seeing.

 

Today we had our first doctor's appointment with an Immunologist and we received a 30 day Rx for Azithromycin. I'm really curious if we'll see a different response since it is more effective at killing off intracellular strep... only time will tell I guess. I'll keep you posted.

 

Has anyone else seen a similar response in their child that was resolved with Azith?

 

-Vicky

[SSS]

Hi,

I'm way, WAY too new to offer any worthy advice, I am in the 'wait' period as well, which is almost unbearable, and I've waited for quite a few things in my life.

We tried Omnicef 1st, on it for 7 days, and my intuition and what I was seeing wasn't 'enough', so asked my Dr. for Azith.

And I am seeing improvement- I guess a part of me was thinking 'poof!' it'd all be gone!

But no.

However, the rages are fewer and and much shorter duration, better maturity, better cognitively. I can 'see' something is being waged in her little body.

We are only on day 10. There are some bumps, some breakthrough issues- it's not 'poof!' all gone. Better periods, longer better periods, then some steps 'back' to where we were.

Also sent in the Cunningham test- I need to see these results--

PANDAS is a huge game changer-- I have been trying to figure out my dd5 for YEARS. I personally think she has been dealing with this a long while, but then I wonder and want to know FOR SURE.

I need to be patient!

Hope you see wonderful things with Azith. and it helps your little boy--

Sarah &

Samantha 5

[Phasmid]

Azithromycin works very well for my son.