High Mycoplasma IgG

[NancyD]

DD14's Myco P IgG test came back > 5.00 (> 1.09 is considered positive). What does this mean?? With the exception of a minor cold last week DD has been fine. And actually, this was the first time in many years she did not present with behavioral symptoms two weeks before coming down with a cold.

 

Last HD IVIg was in March. ASO and Anti-DNASE B only slightly elevated (nothing compared to 3000 range pre- IVIg. With the exception of high anxiety and OCD she has been doing pretty well. Gets dysregulated when stressed but violent rages and tics still gone. We're waiting for IGX basic lyme panel and complete co-infection panel to come back. IgG, IgM, IgA, IgE, and IgG subclasses all normal. Tetanus Tox IgH is high (1.604).For some strange reason the hospital ran their own lyme test in addition to IGX. Only band that came back positive was p66. Everything else looks normal.

[GraceUnderPressure]

NancyD, I am by no means an expert on mycoplasma testing - I'm in the middle of trying to figure all this stuff out myself as I am waiting to get back test results for my ds7. It's very frustrating (what in this wretched business is not?)

 

As near as I have been able to figure out from digging around online, there is disagreement on what elevated IgG to myco means. It apparently can mean that there was an infection at one time that has passed but the immune system is still activated because of it or there are also those who say that an initial myco infection elevates IgM but that subsequent reinfection only elevates IgG.

 

So those of the former opinion will say abx not necessary; those of the latter opinion will be more inclined to treat. I wouldn't be surprised to run across a 3rd (or more) opinion.

 

It seems that they base its interpretation on what other symptoms the patient is (or is not) having at the time - which, like strep et al, is awkward if you are so unfortunate as to not present with typical sx's.

 

I believe that our family had an earlier exposure to myco p where the initial symptoms improved, but never completely went away - so we've had sort of residual symptoms that come & go according to the strength or weakness of our immune systems.

 

I was thinking maybe ds7 had atypical strep when he first got hit with it back in June, but after reading the sx's of myco p infection, his was a textbook case! This was his 2nd go round with it (unless it was another bug that mirrored its sx's exactly but more mildly?) so I will be doubly interested to see how his testing comes out!

[NancyD]

Interesting. I'll ask Dr. B when we see him next week. Thanks GraceUnderPressure!

[GraceUnderPressure]

Please post what he says here if you can! His opinion on this would carry more weight than most & I would love to hear an answer to these questions from a knowledgeable PANDAS/PITAND perspective!

[NancyD]

Yes, I will.

 

Here's an interesting article to read: www.lymepa.org/autism_future_medicine.pdf

 

According to this Mycoplasma pneumoniae is very high in autism.

 

Also, according to this article...

 

"Infections associated with ASD include Babesia, Bartonella, Blastocystis, Borna virus (animal model), Borrelia burgdorferi and other tick-borne diseases, Chlamydia pneumoniae, Cytomegalovirus, Ehrlichia, Herpes simplex virus, Human herpesvirus-6, Herpes virus

family, Mycoplasma fermentans, Mycoplasma genetalium, Mycoplasma hominis, Mycoplasma pneumoniae, Plasmodium (malaria) , rubella, Rubeola, Shigella, Taenia solium (neurocysticercosis), Toxoplasma gondii (toxoplasmosis), Treponema pallidum pallidum

(syphilis), varicella and other unknown viral and infectious agents."

 

and...

 

"Chronic infections associated with causing ASD include Babesia, Bartonella, Blastocystis, Borrelia burgdorferi, Chlamydia pneumoniae, Cytomegalovirus, Ehrlichia, Human herpesvirus-6 and Mycoplasma (in particular M. fermentans), Plasmodium, T. solium, T. gondaii and

T. pallidum pallidum. Coinfections of B. burgdorferi and M. fermentans associated with ASD are frequently observed in clinical settings."

Edited October 9, 2010 by NancyD

[NancyD]

Another good article on high mycoplasma that NewBeginnings posted on the Lyme forum:

http://www.publichealthalert.org/pdf/2009_07.pdf