Suzan Posted September 28, 2010 Report Posted September 28, 2010 dd9's Igenex test came back. Igenex considers it a negative test. I feel like of sick but I'm not sure why. IgG results, bands 31 and 34 were indeterminant. Band 41 was positive. IgM results - band 41 indeterminant She had an IVIG 25 days before the blood draw and she seems to be a low antibody responder. She has been on zithromax for about a year. What do you all think? I'm sending the results today to the LLMD doc and then we can get an appt. Susan
momofgirls Posted September 28, 2010 Report Posted September 28, 2010 Hi Suzan I understand your feeling of uncertainty regarding your daughter's negative western blot. It may very well be that she does not have lyme but there can be false negatives for various reasons. One reason may be low antibody response as you mentioned but another reason can be elevated immune complexes (C3D). If she has an elevated C3D then it is possible that her antibodies are bound within the complexes creating a false negative. This is common in lyme patients, so I've heard. Have you run this test? I think you are smart to see a lyme doctor just to make sure you have completely ruled out lyme because your daughter's imdeterminate bands are lyme specific. No one can say for sure but its definately worth investigating. Good luck! Kim dd9's Igenex test came back. Igenex considers it a negative test. I feel like of sick but I'm not sure why. IgG results, bands 31 and 34 were indeterminant. Band 41 was positive. IgM results - band 41 indeterminant She had an IVIG 25 days before the blood draw and she seems to be a low antibody responder. She has been on zithromax for about a year. What do you all think? I'm sending the results today to the LLMD doc and then we can get an appt. Susan
MichaelTampa Posted September 28, 2010 Report Posted September 28, 2010 Yes, the 31 and 34 bands are considered lyme specific. Some lyme docs consider the indeterminate to be positive. So, it's really up to interpretation.
Suzan Posted September 28, 2010 Author Report Posted September 28, 2010 Hi Suzan I understand your feeling of uncertainty regarding your daughter's negative western blot. It may very well be that she does not have lyme but there can be false negatives for various reasons. One reason may be low antibody response as you mentioned but another reason can be elevated immune complexes (C3D). If she has an elevated C3D then it is possible that her antibodies are bound within the complexes creating a false negative. This is common in lyme patients, so I've heard. Have you run this test? I think you are smart to see a lyme doctor just to make sure you have completely ruled out lyme because your daughter's imdeterminate bands are lyme specific. No one can say for sure but its definately worth investigating. Good luck! Kim No, we have not run this one yet. Shoot! I guess I'll wait to get to the lyme doc and see what she says and maybe we can get all the next tests run all at one time. Thanks,
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