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If your child is having chronic pain, you might want to check out these articles. The first article I found this weekend and just sent it on to our doctor. The other articles I sent last week and they got our doctors attention. I got a personal phone call from him on Friday. He wanted to run the NR2 subunits NMDA receptors testing. The research is out but the testing is still in research. So the the testing cannot be done. Our doctor called in the 7mg extended release Namenda prescription to be given at a higher dosage. My son was started on the Namenda(memantine) 5 mg pills back in November and it was not until December that he noticed his headache pain levels had dropped some. According to some of the research, it can take up to 6 months for this medication to help. It helps regulate NMDA receptors but according to Wiki it also helps regulate dopamine receptors. http://www.uic.edu/labs/wanglab/PDF/tfp2.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113704/ http://paperity.org/p/4445327/targeting-the-nmda-receptor-subunit-nr2b-for-the-treatment-of-neuropathic-pain
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If you are dealing with any pain issues, these 2 research papers may be of some help. My son was tested for NR 1 subset in November and it was negative. I have requested testing for the NR 2 subset. Had no idea that it could cause allodynia. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113704/ http://paperity.org/p/4445327/targeting-the-nmda-receptor-subunit-nr2b-for-the-treatment-of-neuropathic-pain
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Hi everyone, I thought I should share my story now as it is really starting to affect me physically and emotionally after having 'tic's for between 5-10 years now which I always assumed would stop them selves. However, at the age of 22, they are really affecting my lifestyle. From as far back as I can remember, I have always been fidgety, whereby I would tense either side of my neck, twitch (clench) my buttox or raise my eyebrows (which all occurred at different times and varied in the amount I would do one or the other). The main issue today is my raising of the eyebrows though, which is the main problem affecting my day to day life. I have this constant feeling I need to tense them together (in the middle) which I have no counteracted with (what is hard to explain) a twitch whereby I use the muscles above my ears to pull my skin/muscle back which provides the same satisfaction. This satisfaction I believe is to reduce the tension from the constant headache I have from the minute I wake up till the second I sleep. This problem is affecting me physically as I believe this twitch of the raised eyebrows has reshaped my brow-bone whereby I dislike looking at myself in the mirror/pictures now because it looks like I have caused this facial change. The next problem is the fact it is constantly causing me headaches and worry which has affected my university studies! I did previously get referred to a neurological hospital many years ago which did not achieve any results, however a year ago I did get referred again for a botox injection in my forehead which unfortunately did not work, and due to my studies I did not follow it up. I have since been back to the GP and been forwarded to get this procedure as the first time did not work properly (GP believed they didnt use enough/put it in the correct place). I have used the internet to try find solutions which has recently resulted me in increasing my magnesium levels, however it has still not helped! I do hope anyone has some advise for me or if anyone has been through the same could help me solve these tics (if they are even tics!) Regards, Andy
