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I've recently undergone some diagnostic testing for Pans/Pandas, prompted by a strong clinical history and recurrent URI's including chronic sinusitis and petrous apex effusion. The only problem is with the exception of MRI findings, I don't have a single grain of physical evidence! All tests are coming back negative for ASO, ANA, and Mycoplamsa Pneumonia IgM antibodies. I'm finding this whole process very disheartening, especially in the light of my worsening condition and making progress in finding a resolvable cause and explanation. Has anyone else had a similar experience? Does this rule out the possibility of a diagnosis of PANDAS? As I'm not directly under the care of a Pandas friendly physician in my country, all testing has been initiated privately on my behalf from first principle. But I feel like for such a strong clinical history, I'm making no progress in pursuing an effective diagnosis. Any advise is always appreciated. many thanks -
In the middle of October, my son had a strep throat infection and some odd mild PANDAs-like behaviors in the wake of it. (See previous question.) We did a second round of antibiotics and the odd behaviors resolved but my son still seems more irritable//forgetful than before. He's been getting in more trouble at school as well. But you know, he's in fifth grade. It's a tough time. I ended up having his titers run and just got the results: ASO 200 (On this test, 200 is the upper limit of normal.) DNAse-B – 800. (The upper limit of normal on this test is 310.) Are those results abnormal for a child who had a confirmed case of strep 7 weeks ago? Thoughts?
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My son was diagnosed with Pandas in April and I recently got tested. My ASO is 276 (ref range 0-330) and my Dnase is 405 (ref range 0-120). What does this mean? Do I need abx treatment?