Like i said, there are probably "multiple different causes". The histamine gene being one. They showed in rat's low histamine causes tic like behavior's, so I think it's pretty safe to say that's one cause, or at least partially the cause, even if it is in a small minority of tourettes patients. As far as natural antihistamine's, I take omega 3 every day, and I use to take Vitamin C, none of which help my allergies or tic's. Haven't given the other ones you mentioned a try though.