My daughter is on a strange profilactic zith regimen, but her doctor is a "zith" expert, so I'm fine with it. She gets 250mg./day for 5 days(not double dose 1st day, like zpack), then she takes 7 days off. We repeat that. I don't think 1 dose every 5 days would work for my daughter- we begin seeing symptom return on @ day 4 of her "off" period. We see dramatic improvements w/in an hour of her 1st dosage at the beginning of her on cycle. Her doctor's theory is that zith is anti-inflamatory, and that's why it works so well when other antibiotics don't.