Wow, so don't know how things are going now, but I'll add my two cents. According to Dr. Ben Lynch, high-dose niacin can be good for people with serotonin issues (depression, etc.). Now, I realize niacin is a methyl mop, but I think it is about finding a balance. With COMT, you don't want to be over methylated. It can cause depression, irritability & anger. I've seen this in my son, who is COMT, MTRR, MTHFR, amd some others. He was on 5000mcg methylcobalomin daily. We switched him to hydroxycobalamin (the body can convert it to whatever form it needs + it doesn't have methyl groups). It was like night & day. He became happy and more compliant. It may be that your son needs to be on high-dose niacin & high doses oh hydroxycobalamin to address seritonin & MTRR. Hydroxy allows you to use other methyl-containng supplements like methlyfolate. There are other supps that are methyl donors. I think you need to get the right balance of niacin & methyl groups. Inthink the niacin will mostly mop up only excess methyl groups. Check out what Dr. Ben has to say about it. Some People have tried it with good results. And when I say high dose, I think he recommends 500mg niacin daily for adults. Don't know about kids.
