Yes - currently we use this every four months. My daughter's neurotransmitters were extremely disrupted - very high glutamate, very low dopamine and much more. We were able to get her ntransmitters back in line over several months, but the only NeuroScience supplement we were able to use in this effort was Kavinace. My daughter reacts badly to anything methylated - b vitamins or whatever. If you don't have this trouble their supplementation plan may well be helpful to you.