explanation on antineuronals and pandas/Tourette's

[eljomom]

I'm wondering if there are any reports or explanations here regarding the antineuronal numbers on Cunninghams tests and how they may help decipher between Tourette's and pandas?? Dr. L was more interested in those numbers than the Cam K of 168 for some reason. The paper that Cunningham sends only talks about Cam K (the one with the charts/graphs).

Thanks

[Phasmid]

Until there is something published, solidly scientific, nobody knows.

[norcalmom]

try googleing the specific anti-neuronal. Some of them are linked to other movement as well as heart disorder. I think anti-lysoganglioside has some movement stuff linked to it. There are lots of papers out there on these anti-neuronals, as well as Cam K.. Cunningham seems to have chosen to look for anti-neuronals that have been investigated before in other disorders. Since there are hundreds, and she is only looking for four, I'm assuming she has a reason in looking for the four she picked.

 

LEtter from Cunningham regarding Cam K and antineuronals:

http://www.facebook.com/topic.php?uid=104887432702&topic=16040

 

Tubulin and SC:

http://www.jimmunol.org/content/178/11/7412.full

 

Interesting tests they run at this center for movement disorder:

http://neuromuscular.wustl.edu/over/labdis.html

 

This article (supporter of pandas threory - an neurologist in London) references alot of ther articles at the end. You could look up those articles for more information.

"Anti-basal ganglia anti- bodies (ABGA) are found in the majority of subjects with Sydenham’s chorea.1,2 More recently other neu- ropsychiatric disorders or phenotypes have also been associated with ABGA. These include Tourette’s syn- drome,3 adult-onset tic disorders,4 obsessive-compulsive disorder (OCD),5 paediatric autoimmune neuropsychi- atric disorders associated with streptococcal infections (PANDAS),6,7 dyskinesias,8 dystonia,9 post-streptococcal acute disseminated encephalomyelitis (ADEM),10 myoclonus11 and post-encephalitic Parkinsonism or encephalitis lethargica.12 "

 

http://www.acnr.co.uk/pdfs/volume5issue4/v5i4revgiovan.pdf

 

http://bjp.rcpsych.org/cgi/content/full/bjprcpsych;187/4/314

 

http://scholar.google.com/scholar?q=anti-tubulin+antibodies+disorders&hl=en&as_sdt=0&as_vis=1&oi=scholart

 

 

 

There's lots more...have fun reading.

[eljomom]

Just seems to say that these are elevated in pandas AND tourettes---which makes it very difficult to decide treatment:(