Good article on blood brain barrier disruption

[dut]

Hi - What I could understand of this article was interesting. Someone more scientifically minded might know how much bearing it might hold for future treatment possibilities for PANDAS.

 

Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling

 

http://www.fasebj.org/cgi/content/full/21/13/3666

 

 

 

Also quick question on this topic for those with good brains/knowledge...

 

If you have crappy endothelial tight junctions in your BBB might it hold that what is causing a problem there could also cause crappy tight junctions in the GI? So like a double whammy .. bigger than usual molecules getting through there and also at the BBB?

 

I was thinking more for those who have issues(eg on the autism spectrum but not exclusively) with, say gluten and casein.