Pyroluria for the mom who sent me email

[Claire]

Sorry, I don't have an anonymous email address to respond to questions. If you will register on Latitudes and send a private message, I can respond to that.

 

You sound off to a terrific start.

 

It is hard to find internet info on Pyroluria, but if you have the test done at the Direct Health Care clinic, they may be able to fax you information (they did for me). Since your son was borderline, I recommend retesting at this DHC clinic--they SEEM to get higher numbers. 847-222-9546 Be sure to wrap the sample in foil immediately freeze the sample in the freezer for two days. We got a 12, then an 18, then at this lab a 62. Don't know if it is the lab or if things got worse in a month--hard to believe they got that much worse during summer, I think it is at least in part the lab. e.g. I would make sure the number is accurate, given your child has symptoms.

 

I think treating my son's pyroluria made a difference. We did a couple of things then, but based on the timing, I think it was the B6/zinc for the pyroluria that did it.

 

Check out this site--they call it Pyrolle Disorder in the index on this page; also look under the B6 and zinc links, they discuss it more.

 

http://www.alternativementalhealth.com/art...icles/walsh.htm

If you do a google search on that site, you will find out a lot.

 

Here is something else on itI don't have a link--you need to check your own sources of course.

 

------------------

Woody R. McGinnis M.D., Ashland OR

 

Urinary pyrrole, "Mauve Factor" for its chromatographic appearance, was found elevated in 60% of schizophrenics four decades ago by Hoffer, who reported that high doses of niacinamide lowered pyrrole levels, and that symptoms improved accordingly.

Pfeiffer introduced successful treatment with zinc, vitamin B6 and generous anti-oxidants. Many thousands of patients have responded to these approaches, often dramatically.

 

The frequency of elevated pyrrole is 70% in Down syndrome (Jackson, Riordan), 50% in autism (Audhya), 40% in alcoholism (Mathews-Larson), and 30% in ADHD (Walsh). Irrespective of l behavioral diagnosis, elevation is associated with poor tolerance of physical and emotional stress, which increases urinary levels and necessitates dosing adjustments. Low red cell (Audhya) and white cell (McLaren-Howard) zinc levels correlate with pyrrole levels, as do zinc (and B6) requirements, which may be great.

 

Mauve Factor is unstable in presence of light, and was mis- identified as kryptopyrrole (KP) until improved technology in 1976 established that hydroxyhemopyrrolin-2-one (OHHPL), a hydroxy- lactam of hemopyrrole, is Mauve Factor, or at least its key moiety.

Laboratories use KP or OHHPL as standard for this economical test.

 

OHHPL inhibits heme synthesis (Graham). Experimentally, heme inhibition results in lower cellular zinc, and higher iron and oxidative- stress levels (Ames). Heme-dependent enzymes, which play key roles in anti-oxidant defense, include catalase, peroxidase, NO-synthase, cystathionine synthase, heme-hemopexin (synthesis of metallothionein), p450, and cytochromes for energy production.

 

Mauve Factor is strongly associated with depletion of arachidonic acid (Bibus), which is attacked by free radicals to form levuglandins and isolevuglandins, which in turn produce pyrrolic tissue adducts.

These pyrrolic adducts consistently auto-oxidize to form a hydroxy- lactam (Salomon), and the pyrrolic moiety of these adducts corres- ponds precisely to the structure of OHHPL. Urinary pyrroles are known to result from the formation of pyrrolic tissue adducts (Batoreu).

 

Thus, Mauve Factor appears to derive from oxidative injury to lipid and protein. Current research seeks to correlate Mauve Factor with glutathione with glutathione, GSH-peroxidase, lipoperoxide, isoprostane, and apoptosis levels. The clinical experience with Mauve Factor in the abnormal behaviors should heighten interest in the causal role of oxidative stress and advance treatment for these disorders.

 

-----

 

If you have other questions, it is best to post, so that others can benefit. But private messages are okay too. I just can't do email.

 

Claire

[bon]

hi iam not sure that my son has this condtion however he does shows outurts of anger and confession do you think is can be pyroluria he has times that h e does nor untands and his temper can be very exploxsive can you hekp

bonnie tthoulis@comcast.net

thank-you