One of the better articles on S. Pyogenes

[sf_mom]

Its very interesting, not too complicated and also has a great diagram on the Pathogenesis of Streptococcus pyogenes infections (areas it reaches).

 

http://www.tjclarkinc.com/bacterial_diseas...us_pyogenes.htm

 

 

 

This is important too:

 

The capsule of S. pyogenes is non antigenic since it is composed of hyaluronic acid, which is chemically similar to that of host connective tissue. This allows the bacterium to hide its own antigens and to go unrecognized as antigenic by its host The cytoplasmic membrane of S. pyogenes contains some antigens similar to those of human cardiac, skeletal, and smooth muscle, heart valve fibroblasts, and neuronal tissues, resulting in molecular mimicry and a tolerant or suppressed immune response by the host.

[smartyjones]

oh SF mom - 'not too complicated' - you give me too much credit! i'm trying to understand what you're trying to get across lately but my head is starting to spin.

 

you're saying you believe pandas is caused by a particular strain of strep? what to do about it?

 

thanks.

[sf_mom]

Not specifically... but I am trying to get across that if it was the S. Pyogenes strain that your child has, it is toxic and a whole different immune response is believed to kick in.... So, potentially no raised ASO titers or Anti-DNAse-B unless they had been exposed to other strains.

 

I also want parents to know how resilient this particular strain is and why your child might suffer from repeated strep events (still might be original infection that was never fully eradicated within host). If you have attempted to aggressively rid your child of strep and it keeps coming back even on antibiotics its time to consider more aggressive measures. It also discusses how far reaching the bacteria is and how many, many issues can be attributed to this particular strains..... i.e. the graphic included in article.

 

-Wendy

 

 

 

 

 

Its very interesting, not too complicated and also has a great diagram on the Pathogenesis of Streptococcus pyogenes infections (areas it reaches).

 

http://www.tjclarkinc.com/bacterial_diseas...us_pyogenes.htm

 

 

 

This is important too:

 

The capsule of S. pyogenes is non antigenic since it is composed of hyaluronic acid, which is chemically similar to that of host connective tissue. This allows the bacterium to hide its own antigens and to go unrecognized as antigenic by its host The cytoplasmic membrane of S. pyogenes contains some antigens similar to those of human cardiac, skeletal, and smooth muscle, heart valve fibroblasts, and neuronal tissues, resulting in molecular mimicry and a tolerant or suppressed immune response by the host.

[peglem]

Its very interesting, not too complicated and also has a great diagram on the Pathogenesis of Streptococcus pyogenes infections (areas it reaches).

 

http://www.tjclarkinc.com/bacterial_diseas...us_pyogenes.htm

 

 

 

This is important too:

 

The capsule of S. pyogenes is non antigenic since it is composed of hyaluronic acid, which is chemically similar to that of host connective tissue. This allows the bacterium to hide its own antigens and to go unrecognized as antigenic by its host The cytoplasmic membrane of S. pyogenes contains some antigens similar to those of human cardiac, skeletal, and smooth muscle, heart valve fibroblasts, and neuronal tissues, resulting in molecular mimicry and a tolerant or suppressed immune response by the host.

The part I bolded above reminded me of something- How many of your PANDAS kids have "loose" joints? My daughter can become a wet noodle easily! It makes me wonder if the PANDAS affects connective tissue in the joints.

[sf_mom]

I have definitely heard that before 'loose joints'.

 

Its very interesting, not too complicated and also has a great diagram on the Pathogenesis of Streptococcus pyogenes infections (areas it reaches).

 

http://www.tjclarkinc.com/bacterial_diseas...us_pyogenes.htm

 

 

 

This is important too:

 

The capsule of S. pyogenes is non antigenic since it is composed of hyaluronic acid, which is chemically similar to that of host connective tissue. This allows the bacterium to hide its own antigens and to go unrecognized as antigenic by its host The cytoplasmic membrane of S. pyogenes contains some antigens similar to those of human cardiac, skeletal, and smooth muscle, heart valve fibroblasts, and neuronal tissues, resulting in molecular mimicry and a tolerant or suppressed immune response by the host.

The part I bolded above reminded me of something- How many of your PANDAS kids have "loose" joints? My daughter can become a wet noodle easily! It makes me wonder if the PANDAS affects connective tissue in the joints.