STREP PNEUMOCOCCAL ANTIBODY TITER

[sf_mom]

We are tracking Corsa's STREP PNEUMOCOCCAL ANTIBODY TITER post his second IVIG treatment. His blood was drawn 12 days post treatment and he is showing a response in most serotypes. Our plan is to retest on 1/02/2009 to see how quickly he is losing the ability to mount a response to the strep bacteria. If in fact the antibody titers are dropping off and we are seeing a rise in symptoms, we'll retreat with IVIG based on those numbers. My hope is for him to maintain an ability to mount a response.

 

If you remember my son's friend Adrian's STREP PNEUMOCOCCAL ANTIBODY TITER were tested shortly after getting sick with RF (Feb. 2008) and again prior to IVIG treatment (11/2009) we saw a huge depletion over the course of one year.

 

We don't know if it has any meaning yet but I will keep you posted if we see any correlation of symptoms. Sorry, for some reason results are close together so hopefully you can determine first and second set of results. Anything above 2 is showing an ability to mount a response.

 

-Wendy

 

 

LABS: 8/11/2009 12/02/2009

 

Serotype 1: <0.3 1.2

Serotype 3: 1.5 3.5

Serotype 4: 0.3 2.4

Serotype 5: 2.0 3.5

Serotype 8: <0.3 1.4

Serotype 9: <0.3 1.3

Serotype 12: <0.3 0.6

Serotype 14: 0.6 8.0

Serotype 19: 3.5 8.0

Serptype 23: 0.6 2.4

Serotype 26: 4.4 7.4

Serotype 51: 0.4 2.7

Serotype 56: 0.3 2.2

Serotype 68: <0.3 1.8

[KeithandElizabeth]

Wendy:

 

I am a little confused about follow the S. Pneumo titers. I would think that you would see false highs post IVIG from other people's antibodies? And can't many people have low antibody responses to the S. Pneumo if they have not been exposed or if they have recently been ill?

 

I am just thinking aloud...

 

Elizabeth

[sf_mom]

You are correct, you will see false highs after IVIG but he is also showing that he is able to mount an antibody defense against many different strains of strep. As far as an individual having low antibody response to the S. Pneumo if they haven't been exposed theory isn't 'REALLY KNOWN' to be fact by the medical community.

 

How could my son have been exposed to RF, gotten sick, have high CaM Kinase and then showed deficiencies in most titers? We all know he was exposed. How could Adrian have RF, HIGH Anti-DNAse-B of 680 and shown a CONTINUED depletion of those antibodies OVER the period he had active strep infections and he was sick?

 

MY THEORY is, IT, the bacteria, actually attacks the ability to mount a response. See the comments below regarding known strains of strep from RF outbreak in Utah.

 

Two M18 proteins in particular caught the attention of the researchers. They look like another M18 protein, called SPE C, which triggers a massive immune reaction in host cells and leads to streptococcal toxic shock syndrome. Schlievert’s laboratory investigates SPE C and is now studying the newly identified proteins. These types of protein are called superantigens.

 

“Superantigens are interesting molecules because they allow the bacterium to survive in the host for an extended period of time,”

 

So, given that perspective, if Corsa is not exposed to strep and his strep donor antibodies rapidly dissipate...... HOW ARE THOSE DONOR ANTIBODIES BEING UTILIZED? I argue they are being attacked OR utilized COMPLETELY to fight off a bacteria.

 

Feel free to shoot holes in my theory.

 

 

 

Wendy:

 

I am a little confused about follow the S. Pneumo titers. I would think that you would see false highs post IVIG from other people's antibodies? And can't many people have low antibody responses to the S. Pneumo if they have not been exposed or if they have recently been ill?

 

I am just thinking aloud...

 

Elizabeth