More questions about Cunningham study

[peglem]

My daughter tested high to D2. So what does that mean from a practical standpoint? Are D2 recptors being destroyed (attacked?), blocked, activated? I thought I remembered someone saying that it indicates increased dopamine? It seems like knowing this would help in deciding what might be a helpful re: psych meds.

[peglem]

Just bumping this...I think it got lost in the crowd on a busy posting day.

[Suzan]

I would like to know more about these results as well. My dd's were elevated on just about all results. I am imagining as more research is done we will find out so much more. I just wish it was happening now! In case anyone knows the answer to your questions, I'll be watching. I hope my immunologist really will contact Dr. Cunningham and maybe find out more.

 

Susan

[peglem]

Okay, from here:

http://www.latitudes.org/forums/index.php?...lite=cunningham

 

This is an except from an email from Cunningham to Dawn (of this forum-it was pasted by TMOM)

 

The high CaM indicates that your child may have antibodies that signal neuronal cells to release dopamine and cause the PANDAS. the other antibodies are not highly elevated and are within normal levels as you will see when you get the hard copy in the mail.

 

So, then it would make sense that dopamine blockers (like antipsychotics) should help. But, Risperdal made my daughter worse...hmmm.

[peglem]

Forgive my yammering on here- things keep occurring to me and feel like I need to put them down here, to kinda check my understanding.

 

So, hows this:

 

Antibodies from strep are activating the CamKII inside the neuronal cells, causing abnormal signalling. So, is that it, in a nutshell?

And if that's true, does that mean the antibodies are actually not destroying brain cells, but only mucking up neuronal cell signalling?