dut Posted September 4, 2009 Report Posted September 4, 2009 Hello. I was wondering if anyone had any thoughts or saw this in their child.... We tested our d's IgA IgG IgM IgE and subclasses. All came back normal (she had low normal IgA) except IgG4 subclass which came back high and fairly high too. I was expecting to see deficiences if anything, not high levels..... Our ped is following it up but thought I'd ask here too. Thanks.
Suzan Posted September 4, 2009 Report Posted September 4, 2009 Hello. I was wondering if anyone had any thoughts or saw this in their child.... We tested our d's IgA IgG IgM IgE and subclasses. All came back normal (she had low normal IgA) except IgG4 subclass which came back high and fairly high too. I was expecting to see deficiences if anything, not high levels..... Our ped is following it up but thought I'd ask here too. Thanks. Dut, I'll post dd's next week when we get ours back. I'm curious to know what the outcome will be. Please let me know what your Ped comes back with about the high and the low IgA too.... Susan
peglem Posted September 4, 2009 Report Posted September 4, 2009 Your post made me curious. I poked around a bit and found this regarding high IgG4: http://rheumatology.oxfordjournals.org/cgi...t/full/ken336v1
Megs_Mom Posted September 4, 2009 Report Posted September 4, 2009 Your post made me curious. I poked around a bit and found this regarding high IgG4: http://rheumatology.oxfordjournals.org/cgi...t/full/ken336v1 I cannot believe that you found this - and it is fascinating. I love this group. I am putting this in Meg's file for after the immuno work-up is done.
ShaesMom Posted September 4, 2009 Report Posted September 4, 2009 Here is some information on subclasses from the Immune Deficiency Foundation: http://www.primaryimmune.org/publications/...pats/e_ch10.pdf Did you have your d's Pneumococcal titers tested? This test would show how her body actually responds when it has an infection and some doctors and patients believe that this number is actually more important. A person can have normal immunoglobulin levels and still have a problem fighting off infections. The opposite is true as well, a person can low immunologlobulins but have normal responses to the titers and not be considered as having a need for treatment. It is important to look at the overall picture of that person's health--not just the numbers. My daughter has normal immunolglobulins but does not mount a response to any of the titers and therefore is receiving the monthly IVIG.
dut Posted September 5, 2009 Author Report Posted September 5, 2009 just found this too http://www.nextbio.com/b/search/article.nb?id=19136055 From what I can see tho' from article searching it's a symptom of many things just like a headache can be.....
ShaesMom Posted September 5, 2009 Report Posted September 5, 2009 just found this too http://www.nextbio.com/b/search/article.nb?id=19136055 From what I can see tho' from article searching it's a symptom of many things just like a headache can be..... What a find. Very interesting!
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