Can you help me figure this out?

[peglem]

My daughter has been on prophylactic zith for 2 years. She takes 250mg/day for 5 days, then has 7 days off. Before the zith, she had chronic strep that just never, ever cleared, with only behavioral symptoms. Once we started on this zith regimen, behaviors came back on about day 4 off and would resolve within the first couple days of being on it. Gradually, throughout the 1st year, she got to the point where her behaviors on "off days" was indistinguishable from "on days." But, at the beginning of July we started LDN. About 2 weeks into the LDN, I began to notice that the streppy-type behaviors are coming back, but not on the off days. It seems to come back on day1 of her 5 days on zith. On the whole, we've seen some nice improvements on the LDN: a reduction in the frequency, intensity and duration of SIBs, increased communication, increased cooperation and overall better mood. But, what's up with the zith seeming to bring on increases of OCD and erratic movements?

[bmom]

I don't know, but wanted to tell my sons experience. Prior to starting continuous antibiotics, when he would do a round of antibiotics things would get much worse on day one and then much, much better day 2-10. This was his pattern and I could not figure out why. We finally got a doc. to prescribe long term antibiotics and we do not have the stop start problems, but I wanted to let you know that it was the same with my son for some reason.

[peglem]

Thanks for the response. I wonder if, in your case, the death of the bacteria was causing them to release toxins. But Allie was pretty stable on this regimen and if there was ever a problem, it was coming on her "off" days. Even the 1st day back on was good. I can't find anything to support that there would be any conflict or reaction between the zith and the LDN. I'm thinking next time we see her doctor I'll ask about switching her to a different abx, one that does not have immune modulating properties...LDN is supposed to modulate the immune system as well, so maybe there is a problem there. I wonder if we dropped the antibiotic altogether. I wanted to wait til she starts menstruation to do that, but I'm beginning to wonder if she even has a uterus!