Baseline Ig levels predict achievement of remission at 1 yr following IVIg

[jan251]

I don't remember seeing this June 2016 study posted - my apologies if I missed it:

 

PANDAS: Baseline Immunoglobulin Levels Predict Achievement of Remission at One Year Following IVIg Therapy

 

Those who met the diagnostic criteria received IVIg therapy [1.5 g/kg] every eight weeks for up to a year, examined at one month and one year following treatment, and scored for degree of improvement.

Conclusions: Children with PANDAS who had baseline low IgA, IgG or IgG subclass levels were more likely than others to achieve 100 % improvement after IVIg therapy at 12 months follow-up.

The finding of selective humoral deficiencies in children with the most favorable outcome, namely full improvement, should be treated with caution. It does not link the disorder itself to humoral deficiency and it does not provide evidence regarding the optimal dose or duration of therapy. It also does not provide evidence that children’s Ig deficiencies may have increased their susceptibility to repeat GABHS or that repeat GABHS may have contributed to the development of PANDAS symptoms. However, in this small sample from a single pediatric practice, by comparing children with and without Ig deficiencies, we identified a particular subgroup of children with PANDAS who responded favorably to IVIg.

No other study has reported on baseline serum Ig levels in PANDAS or other childhood disorders characterized by tics and OCD in those receiving IVIg therapy [20] although one study found that IVIg alleviated symptom severity when infection triggered the onset of symptoms.

Edited August 21, 2016 by jan251