Specific Antibody Deficiency progress to CVID?

[Sonshine]

DS17 has IGG, IGA and IGM that are lower each time we test. He responded to 6/23 serotypes after Pneumovax.

He has specific antibody deficiency and selective IGM deficiency.

 

IGG went from 1011 to 830 (694-1618)

IGA from 140 to 90 (81-463)

IGM from 40 to 18 (48-271)

 

subclass 3 is low (23)

 

I understand from immunologist that specific antibody deficiency can progress to CVID.

 

Does anyone have experience with this? I thought I understood these levels should be rising into adulthood not dropping?

Edited April 15, 2015 by Sonshine

[Sonshine]

Thanks

Edited April 15, 2015 by Sonshine