ibcdbwc Posted February 20, 2014 Report Share Posted February 20, 2014 If the Cunningham test consists of 5 assays, four of which screen for specified anti neuronal responses, is it possible to have a general screening ANA test report as negative and still have a "highly likely" via Cunningham? I know there are 100s of autoantibodies not necessarily anti nuclear but am having trouble understanding the Cunningham tests - well immunology in general. This is just posted out of curiosity. Link to comment Share on other sites More sharing options...
Rachel Posted February 20, 2014 Report Share Posted February 20, 2014 Was the the ANA done before or after your Cunningham test? My son had a negative ANA test 2 years ago but last October he had a highly likely Cunningham Test after a double ear infection. My son's doctor's are thinking this is some type of immune problem. My son has also had recent testing that indicates problems with viruses. Link to comment Share on other sites More sharing options...
ibcdbwc Posted February 20, 2014 Author Report Share Posted February 20, 2014 We have not done the Cunningham tests. I was just reading about them and wondered about the assays and the specific anti neuronal responses that were being assessed. DS 's ANA is negative, and anti-thyroid antibodies are negative - though he's had reactive thyroiditis with sustained significantly elevated values after flu and parvo and he now requires thyroid treatment. He also has a presence of anti-adrenal antibodies. I guess I was just wondering if there is reason to do a Cunningham test if you have a positive ANA demonstrating autoimmune issues - and vice versa if your ANA is negative will that render 4 out of 5 assays negative? Link to comment Share on other sites More sharing options...
ibcdbwc Posted February 20, 2014 Author Report Share Posted February 20, 2014 Rachel, what testing showed problem with viruses? Titers to specific viruses or immune markers showing a susceptibility to viruses? Trying to learn Link to comment Share on other sites More sharing options...
Rachel Posted February 21, 2014 Report Share Posted February 21, 2014 Our doctor ran a test through LabCorp. I have a copy of these test results. They were ordered as separate test. He ordered the following: Chlamydia pneumoniae IgG, IgM, Parvovirus B19 Human IgG/IgM, Mycoplasma Pneu IgG/IgM, Cytomegalovirus(CMV) IgG, EBV Ab VCA IgG, Anti-DNase B Strep Antibodies,HHV 6 IgG Antibodies, Herpes Simplex Virus I/II IgG, Antistreptolysin O Ab. My son had antibodies that showed high in HHV 6 IgG, Myco P IgG, Parvovirus, and the Anti-DNase. My son started Bixan this last Friday because the Myco P IgG was 953 (normal range is 0-99). I really new to all this also but evidently these high Myco P antibodies are a problem. Three years ago, the titers were high and out of range. Our doctor is going to be running some more testing. When I get those results back, I'll post the information. I don't know what to tell you about the Cunningham Panel. My son had the testing done because of vocal tics that started after throat problem in August 2010 . We thought we had missed something. His first test was done in August 2013 and was neither positive nor negative. My son had a double ear infection in October 2013 and his symptoms flared. He was retested and his results were highly likely. Our doctor is thinking that the Myco P may be the problem. Link to comment Share on other sites More sharing options...
ibcdbwc Posted February 21, 2014 Author Report Share Posted February 21, 2014 Have heard Myco P is a big culprit for many people. Hopefully it will help you add more pieces to the puzzle. Appreciate your feedback. Link to comment Share on other sites More sharing options...
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