Myco P high IGM but

[PowPow]

anyone have any information on what could cause a false high IGM (on any pathogen, really, I guess)?

My child is fine (no pans symptoms at all) now, but myco P was checked, to get a baseline . the IgM is very high- almost 5000! the IgG is also high.

 

I am specifically looking for information regarding how other antibodies can masquerade as myco p. (if they do) or other disorders that may allow an IgM to be so high!

 

These levels have been checked before, during an exacerbation & her levels were high, then, also, but no where near as high as this!

Also, are the antibody levels quantitative?

 

she is doing well now & has been for quite a while, so we are counting are blessings, but very curious now.

 

I know that myco p has been associated with encephalitis, but she is not at that point now at all. She was, but pex, IVig and steroids returned her to us.

 

[Dedee]

When we discovered that my daughter had Myco P our PANS specialist suggested that we test the entire family even though no one in the family had symptoms. My middle son who had shown OCD symptoms in the past but was currently doing well had very high IgG and IgM levels. In fact he had not had any anxiety or OCD symptoms in a couple of years. Myco P can act like lyme in that it can be present in the body but not cause problems for years until activated. Activation can occur by any number of things, other infections, stress, etc... We treated both my daughter and my son and my son's levels came down much quicker than my daughter's. It took almost a year of combo antibiotics to treat my son but over two years to treat my daughter.

 

That was more than two years ago. My son now is in a very bad flare and we are in the process of checking to see if the Myco has returned as this is not unusual. I would absolutely treat. It's not something to mess around with. JMHO.

 

Dedee

[PowPow]

She was on "the combo" for PANS; zithro 500 qd and augmentin 1000 xr bid for a year. This was from her first positive in April 2012. Augmentin was actually probably from fall 2011.

[PowPow]

I am thinking it is not really necessarily indicative of infection. I am wondering if there is research somewhere on false positives, in the sense of hyper igm or other conditions, that may allow antibodies to circulate or not convert to igg.

Thanks for your reply, dedee!