thenmama Posted April 16, 2013 Report Share Posted April 16, 2013 We got dd's (age 13) lab results yesterday (she's been flaring). The labs were run by labcorp, but the anti-dnaseB values are reported with different values than we've gotten in the past. We used to get what looks like a ratio, with dd's always negative at <1:60. Her titer tests have always been negative despite culture confirmed cases of strep (with negative cultures in between and w/ an immune response each time--PANDAS-- so we know she's not a "carrier"). This time her lab results for the ASO was at its usual (barely detected at 7 ish), but her anti-DnaseB values were reported differently and her results were 112 (still within normal, I think the range was 0-170-- I don't have a copy yet, ped called me last night to give me results). I know these are still normal and low relative to other kids with PANDAS, but I'm curious that anything at all registered and am trying to figure things out. Here are my questions for the wise hive: Does anyone know how the values we got translate to the ratios we've gotten in the past? In other words, would this value, 112, be about the same as what she had last test-- which was neg/ <1:60? Would being on antibiotics affect the results? She's on a treatment dose of Augmentin XR (ongoing) and had been on Bactrim for 3-4 days prior to the draw. Would having an immunodeficiency affect the results of these particular tests? She's low in IgG, IgM, IgA. Her IgE was normal this time (used to be a bit high). We've thought we've noticed strep breath over the past few months, but cultures were all neg. In the past we've had mixed results with her swab/culture results when she's said she feels "streppy." The only tests that came back out of range this time were her lymphs (elevated, but I don't have value--ped felt consistent with acute illness) and her low immunoglobulins. I know the titers aren't always accurate-- we've never put much stock in them. Just trying not to leave any stone unturned b/c we can use all the clues we can get. Thanks, all! Link to comment Share on other sites More sharing options...
Mayzoo Posted April 16, 2013 Report Share Posted April 16, 2013 I am not certain how to convert the results, but I bet someone on here will know. Being on ABX should affect the results, but only if the titers had been elevated prior to starting the ABX. Then they should help the titers go down. My kiddos titers are almost the same as yours. She has an ASO of 6 and a dnase of 95 even during an active infection. I suspect my kiddo does not make antibodies to strep which is why her titers are low. We are waiting on lab results that will show her Ig levels (I suspect her levels will indicate an immunodeficiency). If my kiddo (and maybe yours too) does not make antibodies to strep, then strep antibodies are not her trigger. We are waiting for numerous lab results that will show if she has a common co-infection that could be the trigger. Her new immunologist agrees with all my suspicions. Strep breath and sinus infection breath are similar in my kiddo. We recently had kiddos tonsils removed and that has helped her strep breath. She had an active infection in her tonsils despite a year of ABX (actinomyces). My kiddo's lymph nodes are swollen and sensitive to the touch. That is a sign of immunodeficiency. Does your kiddo have their tonsils still? Has your kiddo been evaluated by an ENT? We had been told over the last year that kiddo's tonsils look fine even when she had strep. Even the evaluating ENT said they look fine. Upon remove, they were hypotrophic and consistent with chronic infection. Link to comment Share on other sites More sharing options...
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