Reaction to antibiotics?

[sdrew99]

Has anyone's child had a reaction to antibiotics?

 

Before the PANDAS dx, Sydney had strep (no symptoms) and was given Omnicef for 10 days. It took a few days, but we saw a DEFINITE improvement in her behavior (rages went away, etc.) She was good...meaning no rages, no noticeable change in behavior for about a month. The only things that were happening were that she had (what I assumed was Fifth's disease) a rash, achy joints and sore throat during this time that created a "mini" flare. The rash has come and gone over the past month. It honestly looks like strep rash, but she is negative for strep right now (despite high titers)

 

We saw the neuro last Monday (the 30th) and based on her bloodwork, confirmed PITAND or PANDAS. She was given Omnicef 250/5mL - she was to take it once a day for the next 3 months.

 

We gave her her first dose last Monday, and since then, her behavior has completely gone back to what it was before her FIRST round of Omnicef. She's been on it for 10 days now, and she's been having rages, etc.

 

I called the neuro today after I locked myself in my room and she pounded on my door for 20 minutes. I reported that her behavior has gone haywire since starting Omnicef, and also that her rash has come back (not right away after starting Omnicef, but a few days after - it comes and goes).

 

Her blood work showed positive for Epstein-Barr virus, positive for strep titers and positive for Mycoplasma. But her chest x-ray was negative.

 

So....neuro had us stop Omnicef and we are going to try Zithromax for 10 days.

 

What do you all think? I'm confused because last time, the Omnicef totally cleared her up and her behavior change was for the better. This time... her behavior is WORSE (even she said to me 3 times - "mommy, the medicine is making me worse!") she's also complaining of a sore throat the last 3 days and the rash is back.

 

I just don't know what to think. I'm glad we are trying Zithromax, but I'm curious as to what y'all think.

[AmySLP]

Amoxicillin will cause rash when given with EBV as a reaction...is it possible omnicef can do the same? My daughter had the rash from abx when she had EBV and ES being treated for her chronic strep at that time.

 

Good luck!

 

Amy

[LNN]

It's possibly an allergic reaction, even tho she'd had omnicef before. Or, given that she has EBV and myco, this could be a lyme or bartonella rash. The worsening behavior could be a herx. I'd consider testing her. You can also look at rash examples here: http://sites.google.com/site/drjoneskids/rash-photos At the bottom of the page are links to rashes for co-infections. So there are multiple pages of rashes. You'll have to do a little navigation.