LAB INTERPRETATION? Please help....

[Ataloss12]

We received lab results back on our 5 yr old daughter. I have attached the info. that we got from our doctor. Can anyone help me interpret this? ---------

 

1. Streptococcal titers measured three ways are normal. However, see below.

 

2. Mycoplasma titers are negative

 

3. There is no evidence of Lyme disease. The p41 on Lyme IgG is non-specific.

 

4. Immunoglobulins IgG, IgA and IgM are normal. However, several immune quirks are seen

 

A. IgG4 and IgE are both very low (for example IgG4 - expected 36, found 7)

 

B. IgG2 is relatively low (expected 267, found 205)

 

This cluster is seen in 70-80% of children with PANDAS/PANS and I call it the "PANDAS/PANS immunophenotype (PPI). When children with PPI encounter an infectious trigger, PANDAS/PANS symptoms may result.

 

5. Pneumococcal titers are low for 4/7 serotypes - this suggests she may be a "low strep responder"

 

6. Ferritin is low .This can be treated with supplemental iron

 

7. Vitamin D is very low at 15.6 . This can be readily treated with supplemental Vitamin D

 

Thyroid testing is normal, and there is no evidence of autoimmune disease.

 

Overall, her labs are consistent with PANDAS with a silent strep infection.

[colleendonny]

Hi I don't have much answers for you as we are basically in the same boat. DD5 doesnt show any sign of strep in either ASO or DnaseB.

Her IgG's are all normal, weith a few on the low end of normal. Her vitamin D is also on the very low end of normal.

 

Just wanted to say I relate with PANDAS and no sign of strep. Have you tested through IgeneX for Lyme an Co?

Do you see a PANDAS specialist?

Edited May 1, 2012 by colleendonny

[Ataloss12]

All testing was ordered by Dr. T and done through LabCorp. He just sent us those results and we scheduled a phone consultation to discuss. I was just curious if anyone else had these type of results.

[colleendonny]

Hmm, yes ours our similar but DD has a positive IgG for ehrlichiosis. I don't think Dr. T tests for Lyme and co-infections, does he?

 

If your DD hasn't been tested, I suggest you do so through IgeneX. It could be her trigger...

There have been parents here whose kids have gotten PANDAS/ PANS/ PITAND from viral infections and vaccinations. Did she recently get a vax? Did Dr. T advise you on no more vax?

Where do you live?

[colleendonny]

Oops, Just see Dr. T did test for Lyme. Not sure who he used, or if he tested for co- infections, but it's just another thing to look into. How is your DD? Is she on abx?

[Ataloss12]

Hmm, yes ours our similar but DD has a positive IgG for ehrlichiosis. I don't think Dr. T tests for Lyme and co-infections, does he?

 

If your DD hasn't been tested, I suggest you do so through IgeneX. It could be her trigger...

There have been parents here whose kids have gotten PANDAS/ PANS/ PITAND from viral infections and vaccinations. Did she recently get a vax? Did Dr. T advise you on no more vax?

Where do you live?

 

No recent vaccinations. We live in Indiana, but lucky to have found Dr. T. She is a little better, but not 100% yet. She hasn't been on antibiotics yet. We just got results back today and will have a consultation to discuss everything in detail. I will address the IgeneX/Lyme/Trigger with him. I am thoroughly confused with all of this!