high IgG subclass 4

[thenmama]

Ds has a very high IgG subclass 4-- about double the top of the range. Both of our kids our deficient in subclass 1, but ds is low in 4 and dd is not. I've seen other posts on here about kids who are high in IgG 4 and was wondering if anyone's research and/or docs have given them any insight into this since it seems some of our kids turn up high. I did come across one thing that mentioned IgG 4 and being prone to skin issues, which is true for my ds, but I haven't found much more beyond that mention.

 

Also, ds is subclass 1 is deficient and he has SADs and is IgM deficient so we're heading to IVIG later this week or next week. Wondering if anyone whose child has a similar subclass profile as ds has done IVIG and how your child has done with it. My dd did great thanks to her IVIG, but they present a bit differently.

 

 

TIA!

[nicklemama]

DS has no deficiencies. He had/has high IgG subclass 4. He's had IVIG and doing very well. We have not retested him. He has been found to have environmental allergies and recently started on allergy meds. I was told the IgG 4 being high is related to allergies. We are currently waiting on the results of food allergy testing.